Сравнение
Plecanatid vs. Selank
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Исследования (прочее)
Исследования (прочее)
Номер CAS
467426-54-6
129954-34-3
Молекулярная масса
1682 g/mol
751.85 g/mol
Период полувыведения
нет данных
0.3 h
Последовательность
нет данных
Thr-Lys-Pro-Arg-Pro-Gly-ProМеханизм действия
Plecanatid
Plecanatide is structurally analogous to the body's own uroguanylin and, like it, activates the GC-C receptor at the gut surface, raising cGMP and fluid secretion. Its pH-dependent activity shifts the effect toward the proximal small intestine.
Selank
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
Доказательная база
Наивысшая доказательность
РКИ на людях
Исследование на людях
Исследования
0
4
из них на людях
0
2
Зафиксированные эффекты
2
3
Открытые противоречия
1
1
Задокументированные нежелательные явления
1
1
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Plecanatid and Selank?
- Plecanatid is classified as "Исследования (прочее)", while Selank is classified as "Исследования (прочее)". Plecanatid: Plecanatide is a 16-amino-acid analog of the body's own uroguanylin and a guanylate cyclase-C (GC-C) agonist. It is approved for chronic idiopathic constipation (CIC) and IBS with constipation (IBS-C). Selank: Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trials are absent; efficacy assessment relies on Russian research literature. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Plecanatid or Selank?
- The highest available evidence level is "РКИ на людях" for Plecanatid and "Исследование на людях" for Selank. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Plecanatid and Selank in Germany and the United States?
- Германия: Plecanatid — Не одобрено, Selank — Не одобрено. США: Plecanatid — Рецептурный, Selank — Не одобрено. These are factual summaries with source and review date on the individual pages.