Vergelijking
Plecanatid vs. Selank
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
467426-54-6
129954-34-3
Molecuulmassa
1682 g/mol
751.85 g/mol
Halfwaardetijd
geen gegevens
0.3 h
Sequentie
geen gegevens
Thr-Lys-Pro-Arg-Pro-Gly-ProWerkingsmechanisme
Plecanatid
Plecanatide is structurally analogous to the body's own uroguanylin and, like it, activates the GC-C receptor at the gut surface, raising cGMP and fluid secretion. Its pH-dependent activity shifts the effect toward the proximal small intestine.
Selank
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane studie
Studies
0
4
waarvan bij mensen
0
2
Geregistreerde effecten
2
3
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
1
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Plecanatid and Selank?
- Plecanatid is classified as "Onderzoek (overig)", while Selank is classified as "Onderzoek (overig)". Plecanatid: Plecanatide is a 16-amino-acid analog of the body's own uroguanylin and a guanylate cyclase-C (GC-C) agonist. It is approved for chronic idiopathic constipation (CIC) and IBS with constipation (IBS-C). Selank: Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trials are absent; efficacy assessment relies on Russian research literature. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Plecanatid or Selank?
- The highest available evidence level is "Humane RCT" for Plecanatid and "Humane studie" for Selank. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Plecanatid and Selank in Germany and the United States?
- Duitsland: Plecanatid — Niet goedgekeurd, Selank — Niet goedgekeurd. Verenigde Staten: Plecanatid — Op recept, Selank — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.