Сравнение
Bremelanotide vs. Terlipressin
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Исследования (прочее)
Исследования (прочее)
Номер CAS
189691-06-3
14636-12-5
Молекулярная масса
1025.18 g/mol
1227.37 g/mol
Период полувыведения
2.7 h
нет данных
Последовательность
Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OHнет данных
Механизм действия
Bremelanotide
Bremelanotide is a cyclic peptide that binds non-selectively to melanocortin receptors (MC1R through MC5R) — with highest affinity at MC4R in the central nervous system. The precise role of MC4R activation in sexual behaviour is not fully understood; animal data show effects on hypothalamic circuits. Peripheral effects (blood pressure, hyperpigmentation) are attributed to MC1R/MC2R.
Terlipressin
Terlipressin is slowly converted in the body to lysine-vasopressin by cleavage of the three N-terminal glycyl residues (reservoir effect) and activates V1 receptors. The splanchnic vasoconstriction improves renal perfusion in hepatorenal syndrome.
Доказательная база
Наивысшая доказательность
РКИ на людях
РКИ на людях
Исследования
5
1
из них на людях
5
1
Зафиксированные эффекты
3
2
Открытые противоречия
1
0
Задокументированные нежелательные явления
2
1
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Bremelanotide and Terlipressin?
- Bremelanotide is classified as "Исследования (прочее)", while Terlipressin is classified as "Исследования (прочее)". Bremelanotide: Synthetic cyclic heptapeptide acting as a non-selective melanocortin-receptor agonist. FDA-approved in 2019 as Vyleesi for hypoactive sexual desire disorder (HSDD) in pre-menopausal women. Terlipressin: Terlipressin is a 12-amino-acid vasopressin analog and prodrug of lysine-vasopressin. As a V1 receptor agonist it is vasoconstrictive and is approved for hepatorenal syndrome (FDA 2022, Terlivaz). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Bremelanotide or Terlipressin?
- The highest available evidence level is "РКИ на людях" for Bremelanotide and "РКИ на людях" for Terlipressin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Bremelanotide and Terlipressin in Germany and the United States?
- Германия: Bremelanotide — Не одобрено, Terlipressin — Рецептурный. США: Bremelanotide — Рецептурный, Terlipressin — Рецептурный. These are factual summaries with source and review date on the individual pages.