Сравнение
Bremelanotide vs. Triptorelin
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Исследования (прочее)
Исследования (прочее)
Номер CAS
189691-06-3
57773-63-4
Молекулярная масса
1025.18 g/mol
1311.45 g/mol
Период полувыведения
2.7 h
3 h
Последовательность
Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OHpGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2Механизм действия
Bremelanotide
Bremelanotide is a cyclic peptide that binds non-selectively to melanocortin receptors (MC1R through MC5R) — with highest affinity at MC4R in the central nervous system. The precise role of MC4R activation in sexual behaviour is not fully understood; animal data show effects on hypothalamic circuits. Peripheral effects (blood pressure, hyperpigmentation) are attributed to MC1R/MC2R.
Triptorelin
Triptorelin binds with high affinity to the GnRH receptor in the pituitary. After initial stimulation of LH and FSH secretion (flare phase, about 1-2 weeks), receptor desensitisation follows with consecutive gonadotropin suppression. This results in a reversible chemical castration: in men testosterone, in women oestrogen suppression to the postmenopausal range.
Доказательная база
Наивысшая доказательность
РКИ на людях
РКИ на людях
Исследования
5
4
из них на людях
5
4
Зафиксированные эффекты
3
3
Открытые противоречия
1
0
Задокументированные нежелательные явления
2
3
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Bremelanotide and Triptorelin?
- Bremelanotide is classified as "Исследования (прочее)", while Triptorelin is classified as "Исследования (прочее)". Bremelanotide: Synthetic cyclic heptapeptide acting as a non-selective melanocortin-receptor agonist. FDA-approved in 2019 as Vyleesi for hypoactive sexual desire disorder (HSDD) in pre-menopausal women. Triptorelin: Synthetic decapeptide GnRH agonist with increased affinity over native gonadotropin-releasing hormone. FDA- and EMA-approved since the 1980s for prostate cancer, endometriosis and precocious puberty. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Bremelanotide or Triptorelin?
- The highest available evidence level is "РКИ на людях" for Bremelanotide and "РКИ на людях" for Triptorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Bremelanotide and Triptorelin in Germany and the United States?
- Германия: Bremelanotide — Не одобрено, Triptorelin — Рецептурный. США: Bremelanotide — Рецептурный, Triptorelin — Рецептурный. These are factual summaries with source and review date on the individual pages.