Тема · Механизм
Guanylate cyclase-C agonists
Guanylate cyclase-C (GC-C) agonists (e.g. linaclotide, plecanatide) activate the GC-C receptor on the luminal gut surface, raising cyclic GMP and fluid secretion into the lumen. Approved for IBS with constipation (IBS-C) and chronic idiopathic constipation (CIC).
Peptides on this topic
2 пептидов с исследованиями по этой темеLinaclotid
Исследования (прочее) · 0 studies
Linaclotide is a 14-amino-acid peptide and guanylate cyclase-C (GC-C) agonist. It is approved for irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC).
Релевантные наблюдения
- РКИ на людяхRelieves constipation and abdominal pain in IBS-C and CIC (FDA/EMA-approved).
Plecanatid
Исследования (прочее) · 0 studies
Plecanatide is a 16-amino-acid analog of the body's own uroguanylin and a guanylate cyclase-C (GC-C) agonist. It is approved for chronic idiopathic constipation (CIC) and IBS with constipation (IBS-C).
Релевантные наблюдения
- РКИ на людяхRelieves CIC and IBS-C (FDA-approved).