Confronto

GHK-Cu vs. Matrixyl

Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.

Identità

Categoria

Cosmetico

N. CAS

49557-75-7

214047-00-4

Peso molecolare

340.4 g/mol

802.06 g/mol

Emivita

nessun dato

Sequenza

GHK

Palmitoyl-Lys-Thr-Thr-Lys-Ser

Meccanismo d'azione

GHK-Cu

Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. In skin-cell models and skin biopsies an influence on collagen synthesis, antioxidant markers, gene-expression profiles and wound-healing processes has been described. In topical use in cosmetic studies, changes in various skin parameters have been reported.

Matrixyl

KTTKS is a fragment of the procollagen I sequence and appears to be part of a feedback mechanism in fibroblasts: elevated concentrations signal intact collagen synthesis and downregulate new synthesis, while low concentrations stimulate it. In cell-culture studies, stimulation of collagen types I/III, elastin, fibronectin and glycosaminoglycans has been documented. The palmitoyl modification is intended to improve skin penetration; effect at the site of action (dermal fibroblasts) depends on permeation.

Base di evidenze

Evidenza più alta

Studio sull'uomo

RCT sull'uomo

Studi

di cui sull'uomo

Effetti registrati

Contraddizioni aperte

Eventi avversi documentati

Stato legale

Country	GHK-Cu	Matrixyl
Svizzera	Non approvato	—
Germania	Non approvato	Non approvato
EU	—	Non approvato
Stati Uniti	Non approvato	Non approvato

Voci complete

Frequently asked questions

What is the difference between GHK-Cu and Matrixyl?: GHK-Cu is classified as "Cosmetico", while Matrixyl is classified as "Cosmetico". GHK-Cu: Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. Studied in skin models and small human trials on collagen synthesis, skin regeneration and wound healing; permitted as a cosmetic ingredient in the EU. Matrixyl: Synthetic pentapeptide (KTTKS) with a palmitoyl modification, marketed as a topical anti-aging ingredient (Lipotec/Sederma). Structurally derived from a collagen-I fragment; intended to stimulate fibroblast activity. Cosmetic ingredient, not a medicine. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, GHK-Cu or Matrixyl?: The highest available evidence level is "Studio sull'uomo" for GHK-Cu and "RCT sull'uomo" for Matrixyl. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of GHK-Cu and Matrixyl in Germany and the United States?: Germania: GHK-Cu — Non approvato, Matrixyl — Non approvato. Stati Uniti: GHK-Cu — Non approvato, Matrixyl — Non approvato. These are factual summaries with source and review date on the individual pages.

Country

GHK-Cu

Matrixyl

Svizzera

Non approvato

—

Germania

Non approvato

—

Non approvato

Stati Uniti

Non approvato

Frequently asked questions

What is the difference between GHK-Cu and Matrixyl?

GHK-Cu is classified as "Cosmetico", while Matrixyl is classified as "Cosmetico". GHK-Cu: Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. Studied in skin models and small human trials on collagen synthesis, skin regeneration and wound healing; permitted as a cosmetic ingredient in the EU. Matrixyl: Synthetic pentapeptide (KTTKS) with a palmitoyl modification, marketed as a topical anti-aging ingredient (Lipotec/Sederma). Structurally derived from a collagen-I fragment; intended to stimulate fibroblast activity. Cosmetic ingredient, not a medicine. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, GHK-Cu or Matrixyl?

The highest available evidence level is "Studio sull'uomo" for GHK-Cu and "RCT sull'uomo" for Matrixyl. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of GHK-Cu and Matrixyl in Germany and the United States?

Germania: GHK-Cu — Non approvato, Matrixyl — Non approvato. Stati Uniti: GHK-Cu — Non approvato, Matrixyl — Non approvato. These are factual summaries with source and review date on the individual pages.