Vergelijking

GHK-Cu vs. Matrixyl

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Cosmetisch

CAS-nr.

49557-75-7

214047-00-4

Molecuulmassa

340.4 g/mol

802.06 g/mol

Halfwaardetijd

geen gegevens

Sequentie

GHK

Palmitoyl-Lys-Thr-Thr-Lys-Ser

Werkingsmechanisme

GHK-Cu

Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. In skin-cell models and skin biopsies an influence on collagen synthesis, antioxidant markers, gene-expression profiles and wound-healing processes has been described. In topical use in cosmetic studies, changes in various skin parameters have been reported.

Matrixyl

KTTKS is a fragment of the procollagen I sequence and appears to be part of a feedback mechanism in fibroblasts: elevated concentrations signal intact collagen synthesis and downregulate new synthesis, while low concentrations stimulate it. In cell-culture studies, stimulation of collagen types I/III, elastin, fibronectin and glycosaminoglycans has been documented. The palmitoyl modification is intended to improve skin penetration; effect at the site of action (dermal fibroblasts) depends on permeation.

Bewijsbasis

Hoogste bewijs

Humane studie

Humane RCT

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	GHK-Cu	Matrixyl
Zwitserland	Niet goedgekeurd	—
Duitsland	Niet goedgekeurd	Niet goedgekeurd
EU	—	Niet goedgekeurd
Verenigde Staten	Niet goedgekeurd	Niet goedgekeurd

Volledige vermeldingen

GHK-Cu

Volledige vermelding →

Matrixyl

Volledige vermelding →

Frequently asked questions

What is the difference between GHK-Cu and Matrixyl?: GHK-Cu is classified as "Cosmetisch", while Matrixyl is classified as "Cosmetisch". GHK-Cu: Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. Studied in skin models and small human trials on collagen synthesis, skin regeneration and wound healing; permitted as a cosmetic ingredient in the EU. Matrixyl: Synthetic pentapeptide (KTTKS) with a palmitoyl modification, marketed as a topical anti-aging ingredient (Lipotec/Sederma). Structurally derived from a collagen-I fragment; intended to stimulate fibroblast activity. Cosmetic ingredient, not a medicine. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, GHK-Cu or Matrixyl?: The highest available evidence level is "Humane studie" for GHK-Cu and "Humane RCT" for Matrixyl. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of GHK-Cu and Matrixyl in Germany and the United States?: Duitsland: GHK-Cu — Niet goedgekeurd, Matrixyl — Niet goedgekeurd. Verenigde Staten: GHK-Cu — Niet goedgekeurd, Matrixyl — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.

Country

GHK-Cu

Matrixyl

Zwitserland

Niet goedgekeurd

—

Duitsland

Niet goedgekeurd

—

Niet goedgekeurd

Verenigde Staten

Niet goedgekeurd

Frequently asked questions

What is the difference between GHK-Cu and Matrixyl?

GHK-Cu is classified as "Cosmetisch", while Matrixyl is classified as "Cosmetisch". GHK-Cu: Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. Studied in skin models and small human trials on collagen synthesis, skin regeneration and wound healing; permitted as a cosmetic ingredient in the EU. Matrixyl: Synthetic pentapeptide (KTTKS) with a palmitoyl modification, marketed as a topical anti-aging ingredient (Lipotec/Sederma). Structurally derived from a collagen-I fragment; intended to stimulate fibroblast activity. Cosmetic ingredient, not a medicine. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, GHK-Cu or Matrixyl?

The highest available evidence level is "Humane studie" for GHK-Cu and "Humane RCT" for Matrixyl. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of GHK-Cu and Matrixyl in Germany and the United States?

Duitsland: GHK-Cu — Niet goedgekeurd, Matrixyl — Niet goedgekeurd. Verenigde Staten: GHK-Cu — Niet goedgekeurd, Matrixyl — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.