Confronto

Ipamorelin vs. Tesamorelin

Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.

Identità

Categoria

Crescita

N. CAS

170851-70-4

901758-09-6

Peso molecolare

711.86 g/mol

5135.83 g/mol

Emivita

2 h

0.4 h

Sequenza

Aib-His-D-2-Nal-D-Phe-Lys-NH2

trans-3-hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2

Meccanismo d'azione

Ipamorelin

Ipamorelin is a selective agonist at the GH secretagogue receptor (GHSR-1a). Compared to GHRP-2 and GHRP-6 its selectivity for the growth-hormone axis is higher; ACTH, cortisol and prolactin are not significantly stimulated in clinical studies. This selectivity was the main reason for its development over older GHRPs.

Tesamorelin

Tesamorelin is an N-terminally modified 44-amino-acid version of human GHRH(1-44). A 3-hexenoyl modification protects against rapid dipeptidyl-peptidase-IV cleavage. Binding to the pituitary GHRH receptor stimulates endogenous pulsatile growth-hormone secretion and consequently hepatic IGF-1 production.

Base di evidenze

Evidenza più alta

RCT sull'uomo

Studi

di cui sull'uomo

Effetti registrati

Contraddizioni aperte

Eventi avversi documentati

Stato legale

Country	Ipamorelin	Tesamorelin
Canada	—	Su prescrizione
Germania	Non approvato	Non approvato
Stati Uniti	Non approvato	Su prescrizione

Voci complete

Frequently asked questions

What is the difference between Ipamorelin and Tesamorelin?: Ipamorelin is classified as "Crescita", while Tesamorelin is classified as "Crescita". Ipamorelin: Synthetic pentapeptide and selective growth-hormone secretagogue. Developed at Novo Nordisk in the 1990s as a pentapeptide GHRP successor; clinical development was discontinued after phase 2 (post-operative ileus). Tesamorelin: Stabilised GHRH analog (growth-hormone-releasing hormone). FDA-approved in 2010 as Egrifta for reduction of abdominal lipohypertrophy in HIV-associated lipodystrophy. Not approved for the general population. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Ipamorelin or Tesamorelin?: The highest available evidence level is "RCT sull'uomo" for Ipamorelin and "RCT sull'uomo" for Tesamorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Ipamorelin and Tesamorelin in Germany and the United States?: Germania: Ipamorelin — Non approvato, Tesamorelin — Non approvato. Stati Uniti: Ipamorelin — Non approvato, Tesamorelin — Su prescrizione. These are factual summaries with source and review date on the individual pages.

Country

Ipamorelin

Tesamorelin

Canada

—

Su prescrizione

Germania

Non approvato

Stati Uniti

Non approvato

Su prescrizione

Frequently asked questions

What is the difference between Ipamorelin and Tesamorelin?

Ipamorelin is classified as "Crescita", while Tesamorelin is classified as "Crescita". Ipamorelin: Synthetic pentapeptide and selective growth-hormone secretagogue. Developed at Novo Nordisk in the 1990s as a pentapeptide GHRP successor; clinical development was discontinued after phase 2 (post-operative ileus). Tesamorelin: Stabilised GHRH analog (growth-hormone-releasing hormone). FDA-approved in 2010 as Egrifta for reduction of abdominal lipohypertrophy in HIV-associated lipodystrophy. Not approved for the general population. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Ipamorelin or Tesamorelin?

The highest available evidence level is "RCT sull'uomo" for Ipamorelin and "RCT sull'uomo" for Tesamorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Ipamorelin and Tesamorelin in Germany and the United States?

Germania: Ipamorelin — Non approvato, Tesamorelin — Non approvato. Stati Uniti: Ipamorelin — Non approvato, Tesamorelin — Su prescrizione. These are factual summaries with source and review date on the individual pages.