Vergelijking

Afamelanotide vs. Carbetocin

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

75921-69-6

37025-55-1

Molecuulmassa

1646.87 g/mol

geen gegevens

Halfwaardetijd

12 h

0.67 h

Sequentie

Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

geen gegevens

Werkingsmechanisme

Afamelanotide

Afamelanotide is a synthetic analogue of α-melanocyte-stimulating hormone. It differs from native α-MSH by two substitutions — norleucine at position 4 and D-phenylalanine at position 7 — which make it metabolically more stable and more potent. As an agonist at the melanocortin-1 receptor (MC1R) on melanocytes, it activates adenylate cyclase, raises cAMP and increases tyrosinase activity via the transcription factor MITF. This shifts pigment synthesis toward eumelanin, which absorbs UV and visible light and has antioxidant properties — the presumed mechanism of photoprotection in EPP.

Carbetocin

Carbetocin is an oxytocin receptor agonist with prolonged duration. It triggers a sustained contraction of the uterus after birth, preventing atonic hemorrhage — unlike oxytocin, without a multi-hour infusion.

Bewijsbasis

Hoogste bewijs

Humane RCT

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Afamelanotide	Carbetocin
Duitsland	Op recept	Op recept
EU	Op recept	—
Verenigde Staten	Op recept	Niet goedgekeurd

Volledige vermeldingen

Afamelanotide

Volledige vermelding →

Carbetocin

Volledige vermelding →

Frequently asked questions

What is the difference between Afamelanotide and Carbetocin?: Afamelanotide is classified as "Onderzoek (overig)", while Carbetocin is classified as "Onderzoek (overig)". Afamelanotide: Afamelanotide (brand name Scenesse) is a synthetic 13-amino-acid analogue of α-melanocyte-stimulating hormone (α-MSH) and a melanocortin-1 receptor agonist. Unlike most peptides covered here, it is a regularly approved medicine: EMA approval in 2014/2015, FDA approval in 2019, in each case as a subcutaneous implant for the prevention of phototoxicity in adults with erythropoietic protoporphyria (EPP). It promotes eumelanin formation in the skin. Carbetocin: Carbetocin is a long-acting synthetic oxytocin analog (half-life ~40 minutes). It prevents postpartum hemorrhage as a single injection. Approved in Canada and the UK among others, NOT in the US. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Afamelanotide or Carbetocin?: The highest available evidence level is "Humane RCT" for Afamelanotide and "Humane RCT" for Carbetocin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Afamelanotide and Carbetocin in Germany and the United States?: Duitsland: Afamelanotide — Op recept, Carbetocin — Op recept. Verenigde Staten: Afamelanotide — Op recept, Carbetocin — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.

Country

Afamelanotide

Carbetocin

Duitsland

Op recept

—

Verenigde Staten

Op recept

Niet goedgekeurd

Frequently asked questions

What is the difference between Afamelanotide and Carbetocin?

Afamelanotide is classified as "Onderzoek (overig)", while Carbetocin is classified as "Onderzoek (overig)". Afamelanotide: Afamelanotide (brand name Scenesse) is a synthetic 13-amino-acid analogue of α-melanocyte-stimulating hormone (α-MSH) and a melanocortin-1 receptor agonist. Unlike most peptides covered here, it is a regularly approved medicine: EMA approval in 2014/2015, FDA approval in 2019, in each case as a subcutaneous implant for the prevention of phototoxicity in adults with erythropoietic protoporphyria (EPP). It promotes eumelanin formation in the skin. Carbetocin: Carbetocin is a long-acting synthetic oxytocin analog (half-life ~40 minutes). It prevents postpartum hemorrhage as a single injection. Approved in Canada and the UK among others, NOT in the US. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Afamelanotide or Carbetocin?

The highest available evidence level is "Humane RCT" for Afamelanotide and "Humane RCT" for Carbetocin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Afamelanotide and Carbetocin in Germany and the United States?

Duitsland: Afamelanotide — Op recept, Carbetocin — Op recept. Verenigde Staten: Afamelanotide — Op recept, Carbetocin — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.