Vergelijking

Afamelanotide vs. Vasopressin

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

75921-69-6

geen gegevens

Molecuulmassa

1646.87 g/mol

1084.23 g/mol

Halfwaardetijd

12 h

geen gegevens

Sequentie

Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

geen gegevens

Werkingsmechanisme

Afamelanotide

Afamelanotide is a synthetic analogue of α-melanocyte-stimulating hormone. It differs from native α-MSH by two substitutions — norleucine at position 4 and D-phenylalanine at position 7 — which make it metabolically more stable and more potent. As an agonist at the melanocortin-1 receptor (MC1R) on melanocytes, it activates adenylate cyclase, raises cAMP and increases tyrosinase activity via the transcription factor MITF. This shifts pigment synthesis toward eumelanin, which absorbs UV and visible light and has antioxidant properties — the presumed mechanism of photoprotection in EPP.

Vasopressin

Vasopressin binds V1 receptors (vasoconstriction, raising vascular resistance) and V2 receptors (renal water reabsorption via aquaporin channels). This raises blood pressure and acts antidiuretically. Desmopressin is the V2-selective synthetic analog.

Bewijsbasis

Hoogste bewijs

Humane RCT

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Afamelanotide	Vasopressin
Duitsland	Op recept	Op recept
EU	Op recept	—
Verenigde Staten	Op recept	Op recept

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Afamelanotide

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Vasopressin

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Frequently asked questions

What is the difference between Afamelanotide and Vasopressin?: Afamelanotide is classified as "Onderzoek (overig)", while Vasopressin is classified as "Onderzoek (overig)". Afamelanotide: Afamelanotide (brand name Scenesse) is a synthetic 13-amino-acid analogue of α-melanocyte-stimulating hormone (α-MSH) and a melanocortin-1 receptor agonist. Unlike most peptides covered here, it is a regularly approved medicine: EMA approval in 2014/2015, FDA approval in 2019, in each case as a subcutaneous implant for the prevention of phototoxicity in adults with erythropoietic protoporphyria (EPP). It promotes eumelanin formation in the skin. Vasopressin: Vasopressin (arginine vasopressin, antidiuretic hormone/ADH) is a cyclic nonapeptide hormone that regulates water balance and vascular tone. As Vasostrict it is approved to raise blood pressure in vasodilatory shock. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Afamelanotide or Vasopressin?: The highest available evidence level is "Humane RCT" for Afamelanotide and "Humane RCT" for Vasopressin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Afamelanotide and Vasopressin in Germany and the United States?: Duitsland: Afamelanotide — Op recept, Vasopressin — Op recept. Verenigde Staten: Afamelanotide — Op recept, Vasopressin — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Afamelanotide

Vasopressin

Duitsland

Op recept

—

Verenigde Staten

Op recept

Frequently asked questions

What is the difference between Afamelanotide and Vasopressin?

Afamelanotide is classified as "Onderzoek (overig)", while Vasopressin is classified as "Onderzoek (overig)". Afamelanotide: Afamelanotide (brand name Scenesse) is a synthetic 13-amino-acid analogue of α-melanocyte-stimulating hormone (α-MSH) and a melanocortin-1 receptor agonist. Unlike most peptides covered here, it is a regularly approved medicine: EMA approval in 2014/2015, FDA approval in 2019, in each case as a subcutaneous implant for the prevention of phototoxicity in adults with erythropoietic protoporphyria (EPP). It promotes eumelanin formation in the skin. Vasopressin: Vasopressin (arginine vasopressin, antidiuretic hormone/ADH) is a cyclic nonapeptide hormone that regulates water balance and vascular tone. As Vasostrict it is approved to raise blood pressure in vasodilatory shock. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Afamelanotide or Vasopressin?

The highest available evidence level is "Humane RCT" for Afamelanotide and "Humane RCT" for Vasopressin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Afamelanotide and Vasopressin in Germany and the United States?

Duitsland: Afamelanotide — Op recept, Vasopressin — Op recept. Verenigde Staten: Afamelanotide — Op recept, Vasopressin — Op recept. These are factual summaries with source and review date on the individual pages.