Vergelijking

Cerebrolysin vs. Epitalon

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

96889-70-6

307297-39-8

Molecuulmassa

geen gegevens

390.35 g/mol

Halfwaardetijd

geen gegevens

0.3 h

Sequentie

geen gegevens

Ala-Glu-Asp-Gly

Werkingsmechanisme

Cerebrolysin

Cerebrolysin is a mixture of low-molecular-weight peptides (predominantly below 10 kDa) and free amino acids obtained by enzymatic cleavage of lipid-free porcine brain proteins. The manufacturer and preclinical literature describe a neurotrophic and neuroprotective mode of action said to mimic endogenous neurotrophic factors; cell and animal models have reported effects on neuronal survival, synaptogenesis and anti-apoptotic signalling (including PI3K/Akt). Because it is a complex, incompletely characterised mixture, the precise mechanism in humans remains unclear.

Epitalon

Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.

Bewijsbasis

Hoogste bewijs

Humane RCT

Humane studie

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Cerebrolysin	Epitalon
Oostenrijk	Op recept	—
CN	Op recept	—
Duitsland	Onduidelijk	Niet goedgekeurd
RU	Op recept	Alleen onderzoek
Verenigde Staten	Niet goedgekeurd	Niet goedgekeurd

Volledige vermeldingen

Cerebrolysin

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Epitalon

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Frequently asked questions

What is the difference between Cerebrolysin and Epitalon?: Cerebrolysin is classified as "Onderzoek (overig)", while Epitalon is classified as "Onderzoek (overig)". Cerebrolysin: Cerebrolysin (FPF-1070) is not a single peptide but a porcine-brain-derived preparation of low-molecular-weight peptides and free amino acids, produced by standardised enzymatic proteolysis. It is approved in several countries (including Austria, Russia and parts of Asia) for stroke, dementia and traumatic brain injury, but is not FDA-approved in the United States and not centrally approved by the EMA. Its efficacy is contested: Cochrane systematic reviews found no convincing benefit and flagged possible harm signals. Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Cerebrolysin or Epitalon?: The highest available evidence level is "Humane RCT" for Cerebrolysin and "Humane studie" for Epitalon. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Cerebrolysin and Epitalon in Germany and the United States?: Duitsland: Cerebrolysin — Onduidelijk, Epitalon — Niet goedgekeurd. Verenigde Staten: Cerebrolysin — Niet goedgekeurd, Epitalon — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.

Country

Cerebrolysin

Epitalon

Oostenrijk

Op recept

—

Op recept

—

Duitsland

Onduidelijk

Niet goedgekeurd

Op recept

Alleen onderzoek

Verenigde Staten

Niet goedgekeurd

Frequently asked questions

What is the difference between Cerebrolysin and Epitalon?

Cerebrolysin is classified as "Onderzoek (overig)", while Epitalon is classified as "Onderzoek (overig)". Cerebrolysin: Cerebrolysin (FPF-1070) is not a single peptide but a porcine-brain-derived preparation of low-molecular-weight peptides and free amino acids, produced by standardised enzymatic proteolysis. It is approved in several countries (including Austria, Russia and parts of Asia) for stroke, dementia and traumatic brain injury, but is not FDA-approved in the United States and not centrally approved by the EMA. Its efficacy is contested: Cochrane systematic reviews found no convincing benefit and flagged possible harm signals. Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Cerebrolysin or Epitalon?

The highest available evidence level is "Humane RCT" for Cerebrolysin and "Humane studie" for Epitalon. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Cerebrolysin and Epitalon in Germany and the United States?

Duitsland: Cerebrolysin — Onduidelijk, Epitalon — Niet goedgekeurd. Verenigde Staten: Cerebrolysin — Niet goedgekeurd, Epitalon — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.