Vergelijking

Cerebrolysin vs. Sincalide

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

96889-70-6

25126-32-3

Molecuulmassa

geen gegevens

1143.29 g/mol

Halfwaardetijd

geen gegevens

Sequentie

geen gegevens

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Werkingsmechanisme

Cerebrolysin

Cerebrolysin is a mixture of low-molecular-weight peptides (predominantly below 10 kDa) and free amino acids obtained by enzymatic cleavage of lipid-free porcine brain proteins. The manufacturer and preclinical literature describe a neurotrophic and neuroprotective mode of action said to mimic endogenous neurotrophic factors; cell and animal models have reported effects on neuronal survival, synaptogenesis and anti-apoptotic signalling (including PI3K/Akt). Because it is a complex, incompletely characterised mixture, the precise mechanism in humans remains unclear.

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Bewijsbasis

Hoogste bewijs

Humane RCT

Humane studie

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Cerebrolysin	Sincalide
Oostenrijk	Op recept	—
CN	Op recept	—
Duitsland	Onduidelijk	Onduidelijk
RU	Op recept	—
Verenigde Staten	Niet goedgekeurd	Op recept

Volledige vermeldingen

Cerebrolysin

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Sincalide

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Frequently asked questions

What is the difference between Cerebrolysin and Sincalide?: Cerebrolysin is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Cerebrolysin: Cerebrolysin (FPF-1070) is not a single peptide but a porcine-brain-derived preparation of low-molecular-weight peptides and free amino acids, produced by standardised enzymatic proteolysis. It is approved in several countries (including Austria, Russia and parts of Asia) for stroke, dementia and traumatic brain injury, but is not FDA-approved in the United States and not centrally approved by the EMA. Its efficacy is contested: Cochrane systematic reviews found no convincing benefit and flagged possible harm signals. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Cerebrolysin or Sincalide?: The highest available evidence level is "Humane RCT" for Cerebrolysin and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Cerebrolysin and Sincalide in Germany and the United States?: Duitsland: Cerebrolysin — Onduidelijk, Sincalide — Onduidelijk. Verenigde Staten: Cerebrolysin — Niet goedgekeurd, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Cerebrolysin

Sincalide

Oostenrijk

Op recept

—

Op recept

—

Duitsland

Onduidelijk

Op recept

—

Verenigde Staten

Niet goedgekeurd

Op recept

Frequently asked questions

What is the difference between Cerebrolysin and Sincalide?

Cerebrolysin is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Cerebrolysin: Cerebrolysin (FPF-1070) is not a single peptide but a porcine-brain-derived preparation of low-molecular-weight peptides and free amino acids, produced by standardised enzymatic proteolysis. It is approved in several countries (including Austria, Russia and parts of Asia) for stroke, dementia and traumatic brain injury, but is not FDA-approved in the United States and not centrally approved by the EMA. Its efficacy is contested: Cochrane systematic reviews found no convincing benefit and flagged possible harm signals. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Cerebrolysin or Sincalide?

The highest available evidence level is "Humane RCT" for Cerebrolysin and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Cerebrolysin and Sincalide in Germany and the United States?

Duitsland: Cerebrolysin — Onduidelijk, Sincalide — Onduidelijk. Verenigde Staten: Cerebrolysin — Niet goedgekeurd, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.