Vergelijking

Cetrorelix vs. Octreotide

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

120287-85-6

83150-76-9

Molecuulmassa

1431.06 g/mol

1019.24 g/mol

Halfwaardetijd

geen gegevens

1.7 h

Sequentie

geen gegevens

D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr(ol)

Werkingsmechanisme

Cetrorelix

Cetrorelix competitively and immediately blocks the pituitary GnRH receptor, rapidly suppressing LH and FSH release — without the initial hormone surge ('flare') of GnRH agonists.

Octreotide

Octreotide is a cyclic octapeptide that selectively binds somatostatin-receptor subtypes SSTR2 and SSTR5. Via G-protein-coupled signalling, adenylyl cyclase is inhibited, reducing the secretion of multiple hormones (growth hormone, IGF-1, glucagon, insulin, VIP, serotonin). Structural stabilisation via a disulfide bridge and D-amino acids extends the half-life relative to natural somatostatin (minutes to several hours).

Bewijsbasis

Hoogste bewijs

Humane RCT

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Cetrorelix	Octreotide
Duitsland	Op recept	Op recept
Verenigde Staten	Op recept	Op recept

Volledige vermeldingen

Cetrorelix

Volledige vermelding →

Octreotide

Volledige vermelding →

Frequently asked questions

What is the difference between Cetrorelix and Octreotide?: Cetrorelix is classified as "Onderzoek (overig)", while Octreotide is classified as "Onderzoek (overig)". Cetrorelix: Cetrorelix is a synthetic decapeptide and GnRH antagonist. It is used in assisted reproduction (IVF) to prevent a premature LH surge during controlled ovarian stimulation. Octreotide: Synthetic octapeptide somatostatin analog with a longer half-life than endogenous somatostatin. FDA- and EMA-approved since the 1980s for acromegaly and neuroendocrine tumours. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Cetrorelix or Octreotide?: The highest available evidence level is "Humane RCT" for Cetrorelix and "Humane RCT" for Octreotide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Cetrorelix and Octreotide in Germany and the United States?: Duitsland: Cetrorelix — Op recept, Octreotide — Op recept. Verenigde Staten: Cetrorelix — Op recept, Octreotide — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Cetrorelix

Octreotide

Duitsland

Op recept

Verenigde Staten

Op recept

Frequently asked questions

What is the difference between Cetrorelix and Octreotide?

Cetrorelix is classified as "Onderzoek (overig)", while Octreotide is classified as "Onderzoek (overig)". Cetrorelix: Cetrorelix is a synthetic decapeptide and GnRH antagonist. It is used in assisted reproduction (IVF) to prevent a premature LH surge during controlled ovarian stimulation. Octreotide: Synthetic octapeptide somatostatin analog with a longer half-life than endogenous somatostatin. FDA- and EMA-approved since the 1980s for acromegaly and neuroendocrine tumours. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Cetrorelix or Octreotide?

The highest available evidence level is "Humane RCT" for Cetrorelix and "Humane RCT" for Octreotide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Cetrorelix and Octreotide in Germany and the United States?

Duitsland: Cetrorelix — Op recept, Octreotide — Op recept. Verenigde Staten: Cetrorelix — Op recept, Octreotide — Op recept. These are factual summaries with source and review date on the individual pages.