Vergelijking
Degarelix vs. Sincalide
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
214766-78-6
25126-32-3
Molecuulmassa
1632.3 g/mol
1143.29 g/mol
Halfwaardetijd
1320 h
geen gegevens
Sequentie
Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-4Aph(Hor)-D-4Aph(Cbm)-Leu-Ilys-Pro-D-Ala-NH2Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2Werkingsmechanisme
Degarelix
Degarelix is a competitive GnRH receptor antagonist. It binds reversibly and immediately to the pituitary GnRH receptors and blocks their activation. This rapidly suppresses the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn lowers testosterone production in the testes. Unlike GnRH agonists (e.g., leuprorelin), which first cause a transient stimulation with a testosterone surge (flare), this direct antagonism lacks the initial stimulation phase, so testosterone declines without a preceding rise. This mechanism underlies the literature-described use in hormone-dependent prostate cancer.
Sincalide
Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane studie
Studies
4
0
waarvan bij mensen
4
0
Geregistreerde effecten
4
1
Openstaande tegenstrijdigheden
1
0
Gedocumenteerde bijwerkingen
2
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Degarelix and Sincalide?
- Degarelix is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Degarelix: Degarelix (trade name Firmagon) is a synthetic decapeptide and a gonadotropin-releasing hormone (GnRH) receptor antagonist. Unlike GnRH agonists, it blocks the receptor directly and does not trigger an initial testosterone surge (flare). It is an approved prescription medicine for the treatment of advanced, hormone-dependent prostate cancer. This page neutrally summarizes the evidence base and legal status and is not a usage or dosing recommendation. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Degarelix or Sincalide?
- The highest available evidence level is "Humane RCT" for Degarelix and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Degarelix and Sincalide in Germany and the United States?
- Duitsland: Degarelix — Op recept, Sincalide — Onduidelijk. Verenigde Staten: Degarelix — Op recept, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.