Vergelijking
DSIP vs. Melanotan II
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
62568-57-4
121062-08-6
Molecuulmassa
848.81 g/mol
1024.18 g/mol
Halfwaardetijd
0.1 h
1 h
Sequentie
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-GluAc-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2Werkingsmechanisme
DSIP
DSIP was described in 1977 by the Schoenenberger-Monnier group in Basel as a blood-borne substance reported to induce EEG changes similar to delta sleep in animal models. The exact mechanism remains undefined to this day: no defined receptor, proposed modulation of opioid, GABAergic and glutamatergic systems. Most mechanistic findings stem from preclinical studies of the 1980s and 1990s and were later subjected to contested replication attempts.
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Bewijsbasis
Hoogste bewijs
Humane studie
Humane studie
Studies
4
9
waarvan bij mensen
1
5
Geregistreerde effecten
3
4
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
1
6
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between DSIP and Melanotan II?
- DSIP is classified as "Onderzoek (overig)", while Melanotan II is classified as "Onderzoek (overig)". DSIP: Synthetic nonapeptide isolated in 1977 by Guido Monnier and Marcel Schoenenberger from the blood of rabbits in delta sleep. Despite the name, the role in sleep regulation is contested and not confirmed by Western RCTs in larger populations. Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, DSIP or Melanotan II?
- The highest available evidence level is "Humane studie" for DSIP and "Humane studie" for Melanotan II. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of DSIP and Melanotan II in Germany and the United States?
- Duitsland: DSIP — Niet goedgekeurd, Melanotan II — Niet goedgekeurd. Verenigde Staten: DSIP — Niet goedgekeurd, Melanotan II — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.