Vergelijking
Dulaglutide vs. Pramlintid
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Metabool
Metabool
CAS-nr.
923950-08-7
151126-32-8
Molecuulmassa
59670 g/mol
3949.4 g/mol
Halfwaardetijd
110 h
geen gegevens
Sequentie
GLP-1(7-37)-Variante kovalent verbunden mit modifiziertem humanen IgG4-Fcgeen gegevens
Werkingsmechanisme
Dulaglutide
Dulaglutide consists of two modified GLP-1(7-37) sequences covalently linked to a human IgG4-Fc. The Fc fusion increases molecular weight substantially (~60 kDa), reduces renal filtration and extends the half-life to several days. GLP-1 receptor activation glucose-dependently stimulates insulin secretion, inhibits glucagon, delays gastric emptying and modulates central satiety signalling.
Pramlintid
Pramlintide mimics the beta-cell hormone amylin, which is co-secreted with insulin. It slows gastric emptying, suppresses postprandial glucagon release and promotes satiety — thereby blunting post-meal blood-glucose spikes.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane RCT
Studies
5
0
waarvan bij mensen
5
0
Geregistreerde effecten
3
2
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
2
2
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Dulaglutide and Pramlintid?
- Dulaglutide is classified as "Metabool", while Pramlintid is classified as "Metabool". Dulaglutide: GLP-1 receptor agonist designed as a fusion protein of two modified GLP-1(7-37) sequences covalently linked to a human IgG4-Fc fragment. FDA-approved 2014 (Trulicity) for type 2 diabetes; EMA approval 2014. Pramlintid: Pramlintide is a synthetic analog of the hormone amylin. It is used as an adjunct to mealtime insulin therapy in type 1 and type 2 diabetes and, among other things, slows gastric emptying. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Dulaglutide or Pramlintid?
- The highest available evidence level is "Humane RCT" for Dulaglutide and "Humane RCT" for Pramlintid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Dulaglutide and Pramlintid in Germany and the United States?
- Duitsland: Dulaglutide — Op recept, Pramlintid — Niet goedgekeurd. Verenigde Staten: Dulaglutide — Op recept, Pramlintid — Op recept. These are factual summaries with source and review date on the individual pages.