Vergelijking
Dulaglutide vs. Semaglutid
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Metabool
Metabool
CAS-nr.
923950-08-7
910463-68-2
Molecuulmassa
59670 g/mol
4113.6 g/mol
Halfwaardetijd
110 h
165 h
Sequentie
GLP-1(7-37)-Variante kovalent verbunden mit modifiziertem humanen IgG4-Fcmodifiziertes GLP-1-Analogon (31 AS) mit C18-Fettsäure-LinkerWerkingsmechanisme
Dulaglutide
Dulaglutide consists of two modified GLP-1(7-37) sequences covalently linked to a human IgG4-Fc. The Fc fusion increases molecular weight substantially (~60 kDa), reduces renal filtration and extends the half-life to several days. GLP-1 receptor activation glucose-dependently stimulates insulin secretion, inhibits glucagon, delays gastric emptying and modulates central satiety signalling.
Semaglutid
Long-acting agonist at the GLP-1 receptor. Structurally a modified glucagon-like peptide 1 whose long half-life is achieved via a fatty-acid side chain and reversible albumin binding. Acts centrally on satiety and peripherally on glucose-dependent insulin secretion and delayed gastric emptying.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane RCT
Studies
5
4
waarvan bij mensen
5
3
Geregistreerde effecten
3
3
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
2
5
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Dulaglutide and Semaglutid?
- Dulaglutide is classified as "Metabool", while Semaglutid is classified as "Metabool". Dulaglutide: GLP-1 receptor agonist designed as a fusion protein of two modified GLP-1(7-37) sequences covalently linked to a human IgG4-Fc fragment. FDA-approved 2014 (Trulicity) for type 2 diabetes; EMA approval 2014. Semaglutid: Long-acting GLP-1 receptor agonist. Approved as a medicinal product for type-2 diabetes (Ozempic, Rybelsus), chronic weight management (Wegovy) and cardiovascular risk in obesity. One of the best-studied substances on this platform — many large human RCTs. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Dulaglutide or Semaglutid?
- The highest available evidence level is "Humane RCT" for Dulaglutide and "Humane RCT" for Semaglutid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Dulaglutide and Semaglutid in Germany and the United States?
- Duitsland: Dulaglutide — Op recept, Semaglutid — Op recept. Verenigde Staten: Dulaglutide — Op recept, Semaglutid — Op recept. These are factual summaries with source and review date on the individual pages.