Vergelijking
Dulaglutide vs. VK2735
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Metabool
Metabool
CAS-nr.
923950-08-7
geen gegevens
Molecuulmassa
59670 g/mol
geen gegevens
Halfwaardetijd
110 h
geen gegevens
Sequentie
GLP-1(7-37)-Variante kovalent verbunden mit modifiziertem humanen IgG4-Fcgeen gegevens
Werkingsmechanisme
Dulaglutide
Dulaglutide consists of two modified GLP-1(7-37) sequences covalently linked to a human IgG4-Fc. The Fc fusion increases molecular weight substantially (~60 kDa), reduces renal filtration and extends the half-life to several days. GLP-1 receptor activation glucose-dependently stimulates insulin secretion, inhibits glucagon, delays gastric emptying and modulates central satiety signalling.
VK2735
VK2735 activates both the GLP-1 and the GIP receptor — a dual mechanism similar to that of tirzepatide, suppressing appetite and food intake.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane RCT
Studies
5
1
waarvan bij mensen
5
1
Geregistreerde effecten
3
2
Openstaande tegenstrijdigheden
1
0
Gedocumenteerde bijwerkingen
2
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Dulaglutide and VK2735?
- Dulaglutide is classified as "Metabool", while VK2735 is classified as "Metabool". Dulaglutide: GLP-1 receptor agonist designed as a fusion protein of two modified GLP-1(7-37) sequences covalently linked to a human IgG4-Fc fragment. FDA-approved 2014 (Trulicity) for type 2 diabetes; EMA approval 2014. VK2735: VK2735 is a dual GLP-1/GIP receptor agonist from Viking Therapeutics, in development in both subcutaneous and oral forms for obesity. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Dulaglutide or VK2735?
- The highest available evidence level is "Humane RCT" for Dulaglutide and "Humane RCT" for VK2735. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Dulaglutide and VK2735 in Germany and the United States?
- Duitsland: Dulaglutide — Op recept, VK2735 — Niet goedgekeurd. Verenigde Staten: Dulaglutide — Op recept, VK2735 — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.