Vergelijking
Enfuvirtid vs. Melanotan II
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
159519-65-0
121062-08-6
Molecuulmassa
4491.88 g/mol
1024.18 g/mol
Halfwaardetijd
geen gegevens
1 h
Sequentie
geen gegevens
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2Werkingsmechanisme
Enfuvirtid
Enfuvirtide binds the first heptad-repeat region (HR1) of the gp41 subunit of the HIV envelope protein. This prevents the conformational change required for fusion of the viral and cell membranes — the virus cannot enter the cell.
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane studie
Studies
1
9
waarvan bij mensen
1
5
Geregistreerde effecten
2
4
Openstaande tegenstrijdigheden
0
1
Gedocumenteerde bijwerkingen
1
6
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Enfuvirtid and Melanotan II?
- Enfuvirtid is classified as "Onderzoek (overig)", while Melanotan II is classified as "Onderzoek (overig)". Enfuvirtid: Enfuvirtide is a synthetic 36-amino-acid peptide and the first HIV-1 fusion inhibitor. It binds the HR1 region of the viral envelope protein gp41, blocking viral entry into the cell. Approved for treatment-experienced HIV patients. Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Enfuvirtid or Melanotan II?
- The highest available evidence level is "Humane RCT" for Enfuvirtid and "Humane studie" for Melanotan II. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Enfuvirtid and Melanotan II in Germany and the United States?
- Duitsland: Enfuvirtid — Op recept, Melanotan II — Niet goedgekeurd. Verenigde Staten: Enfuvirtid — Op recept, Melanotan II — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.