Vergelijking
GHRP-2 vs. Ipamorelin
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Groei
Groei
CAS-nr.
158861-67-7
170851-70-4
Molecuulmassa
817.93 g/mol
711.86 g/mol
Halfwaardetijd
0.5 h
2 h
Sequentie
D-Ala-D-2-Naphthyl-Ala-Ala-Trp-D-Phe-Lys-NH2Aib-His-D-2-Nal-D-Phe-Lys-NH2Werkingsmechanisme
GHRP-2
GHRP-2 binds with high affinity to the GH secretagogue receptor (GHSR-1a) in the pituitary and hypothalamus. Activation leads to rapid release of pulsatile growth hormone. Unlike GHRH, GHRP-2 acts via a separate pathway and can be combined synergistically with GHRH to elicit maximal GH responses in provocation tests.
Ipamorelin
Ipamorelin is a selective agonist at the GH secretagogue receptor (GHSR-1a). Compared to GHRP-2 and GHRP-6 its selectivity for the growth-hormone axis is higher; ACTH, cortisol and prolactin are not significantly stimulated in clinical studies. This selectivity was the main reason for its development over older GHRPs.
Bewijsbasis
Hoogste bewijs
Humane studie
Humane RCT
Studies
4
4
waarvan bij mensen
4
3
Geregistreerde effecten
3
3
Openstaande tegenstrijdigheden
0
1
Gedocumenteerde bijwerkingen
1
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between GHRP-2 and Ipamorelin?
- GHRP-2 is classified as "Groei", while Ipamorelin is classified as "Groei". GHRP-2: Synthetic hexapeptide of the GH secretagogue family. Approved in Japan as GHRP Kaken as a diagnostic test for GH deficiency. Not available as a medicine outside Japan. Ipamorelin: Synthetic pentapeptide and selective growth-hormone secretagogue. Developed at Novo Nordisk in the 1990s as a pentapeptide GHRP successor; clinical development was discontinued after phase 2 (post-operative ileus). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, GHRP-2 or Ipamorelin?
- The highest available evidence level is "Humane studie" for GHRP-2 and "Humane RCT" for Ipamorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of GHRP-2 and Ipamorelin in Germany and the United States?
- Duitsland: GHRP-2 — Niet goedgekeurd, Ipamorelin — Niet goedgekeurd. Verenigde Staten: GHRP-2 — Niet goedgekeurd, Ipamorelin — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.