Vergelijking
GHRP-6 vs. MGF (Mechano Growth Factor)
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Groei
Groei
CAS-nr.
87616-84-0
12-Aminosäuren-C-terminales E-Domänen-Peptid (Sequenz nicht standardisiert)
Molecuulmassa
873.02 g/mol
2867.2 g/mol
Halfwaardetijd
0.4 h
0.1 h
Sequentie
His-D-Trp-Ala-Trp-D-Phe-Lys-NH2YQPPSTNKNTKSQRRKGSTFEERKWerkingsmechanisme
GHRP-6
GHRP-6 is a high-affinity agonist of the growth-hormone secretagogue receptor 1a (GHSR-1a) — the same receptor later shown to bind the endogenous hormone ghrelin. The identification of GHRP-6 as a pharmacological anchor led to cloning of GHSR in 1996 and the discovery of ghrelin itself in 1999. GHRP-6 stimulates pituitary GH secretion via a pathway independent of GHRH and can be combined synergistically with GHRH. Via GHSR in the hypothalamus it additionally activates NPY/AgRP neurons, producing an orexigenic (appetite-stimulating) effect in animal models.
MGF (Mechano Growth Factor)
The IGF-1 gene produces multiple isoforms by alternative splicing. IGF-1Ec is upregulated after mechanical muscle loading; the C-terminal E-domain is cleaved from the mature IGF-1 protein and appears to have independent effects on satellite cells. The exact receptor binding of the E-domain is not established; a classical IGF-1R effect is unlikely since mature IGF-1 is responsible. In cell-culture studies, stimulation of myoblast proliferation and differentiation has been observed.
Bewijsbasis
Hoogste bewijs
Humane studie
Diermodel
Studies
4
4
waarvan bij mensen
2
0
Geregistreerde effecten
4
3
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
2
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between GHRP-6 and MGF (Mechano Growth Factor)?
- GHRP-6 is classified as "Groei", while MGF (Mechano Growth Factor) is classified as "Groei". GHRP-6: Synthetic hexapeptide that founded the class of growth-hormone-releasing peptides (GHRPs). Cyril Bowers identified GHRP-6 in the late 1970s as the first orally and parenterally active GH secretagogue with no structural similarity to GHRH. Never approved as a medicine; downstream analogs (GHRP-2, hexarelin, ipamorelin) were pursued clinically. MGF (Mechano Growth Factor): Synthetic peptide corresponding to the C-terminal E-domain of the IGF-1 splice variant IGF-1Ec. Described in preclinical studies as a 'mechano-induced' skeletal muscle repair factor. No marketing approval; clinical use largely confined to the black market. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, GHRP-6 or MGF (Mechano Growth Factor)?
- The highest available evidence level is "Humane studie" for GHRP-6 and "Diermodel" for MGF (Mechano Growth Factor). A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of GHRP-6 and MGF (Mechano Growth Factor) in Germany and the United States?
- Duitsland: GHRP-6 — Niet goedgekeurd, MGF (Mechano Growth Factor) — Niet goedgekeurd. Verenigde Staten: GHRP-6 — Niet goedgekeurd, MGF (Mechano Growth Factor) — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.