Vergelijking
Lanreotid vs. Octreotide
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
108736-35-2
83150-76-9
Molecuulmassa
1096.34 g/mol
1019.24 g/mol
Halfwaardetijd
geen gegevens
1.7 h
Sequentie
geen gegevens
D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr(ol)Werkingsmechanisme
Lanreotid
Lanreotide activates somatostatin receptors (chiefly SSTR2, additionally SSTR5), thereby suppressing the release of growth hormone, IGF-1 and various gastrointestinal and neuroendocrine hormones. It is metabolically far more stable than natural somatostatin.
Octreotide
Octreotide is a cyclic octapeptide that selectively binds somatostatin-receptor subtypes SSTR2 and SSTR5. Via G-protein-coupled signalling, adenylyl cyclase is inhibited, reducing the secretion of multiple hormones (growth hormone, IGF-1, glucagon, insulin, VIP, serotonin). Structural stabilisation via a disulfide bridge and D-amino acids extends the half-life relative to natural somatostatin (minutes to several hours).
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane RCT
Studies
1
5
waarvan bij mensen
1
4
Geregistreerde effecten
2
3
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
2
2
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Lanreotid and Octreotide?
- Lanreotid is classified as "Onderzoek (overig)", while Octreotide is classified as "Onderzoek (overig)". Lanreotid: Lanreotide is a synthetic cyclic octapeptide analog of somatostatin. It binds preferentially to the somatostatin receptors SSTR2 and SSTR5 and is approved for treating acromegaly and certain neuroendocrine tumours. Octreotide: Synthetic octapeptide somatostatin analog with a longer half-life than endogenous somatostatin. FDA- and EMA-approved since the 1980s for acromegaly and neuroendocrine tumours. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Lanreotid or Octreotide?
- The highest available evidence level is "Humane RCT" for Lanreotid and "Humane RCT" for Octreotide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Lanreotid and Octreotide in Germany and the United States?
- Duitsland: Lanreotid — Op recept, Octreotide — Op recept. Verenigde Staten: Lanreotid — Op recept, Octreotide — Op recept. These are factual summaries with source and review date on the individual pages.