Vergelijking
Leuprorelin vs. Melanotan II
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
53714-56-0
121062-08-6
Molecuulmassa
1209.4 g/mol
1024.18 g/mol
Halfwaardetijd
3 h
1 h
Sequentie
Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEtAc-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2Werkingsmechanisme
Leuprorelin
Leuprorelin is a GnRH-receptor agonist. After binding to pituitary GnRH receptors, it first causes a transient surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release — the so-called flare. With continuous, non-pulsatile exposure the receptors are downregulated and desensitized, suppressing gonadotropin secretion and consequently lowering sex steroids (testosterone or estradiol) to low levels. This mechanism underlies the literature-described use in hormone-dependent conditions.
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane studie
Studies
4
9
waarvan bij mensen
4
5
Geregistreerde effecten
4
4
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
3
6
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Leuprorelin and Melanotan II?
- Leuprorelin is classified as "Onderzoek (overig)", while Melanotan II is classified as "Onderzoek (overig)". Leuprorelin: Leuprorelin (also leuprolide) is a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH). It is an approved prescription medicine in several jurisdictions, including for advanced prostate cancer, endometriosis, uterine fibroids and central precocious puberty. This page neutrally summarizes the evidence base and legal status and is not a usage or dosing recommendation. Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Leuprorelin or Melanotan II?
- The highest available evidence level is "Humane RCT" for Leuprorelin and "Humane studie" for Melanotan II. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Leuprorelin and Melanotan II in Germany and the United States?
- Duitsland: Leuprorelin — Op recept, Melanotan II — Niet goedgekeurd. Verenigde Staten: Leuprorelin — Op recept, Melanotan II — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.