Vergelijking
LL-37 vs. Triptorelin
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
597562-32-8
57773-63-4
Molecuulmassa
4493.33 g/mol
1311.45 g/mol
Halfwaardetijd
geen gegevens
3 h
Sequentie
LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTESpGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2Werkingsmechanisme
LL-37
LL-37 is a cationic, amphipathic helical peptide and the only member of the cathelicidin family in humans. It is generated by proteolytic cleavage from the C-terminal portion of the precursor protein hCAP18 (CAP-18). Mechanistically it associates with and can permeabilize microbial membranes; in addition it modulates immune cells, influences cytokine release, exerts chemotactic activity, and can bind extracellular self-DNA. Preclinical models have described both anti-inflammatory and pro-inflammatory effects, depending on concentration and tissue context.
Triptorelin
Triptorelin binds with high affinity to the GnRH receptor in the pituitary. After initial stimulation of LH and FSH secretion (flare phase, about 1-2 weeks), receptor desensitisation follows with consecutive gonadotropin suppression. This results in a reversible chemical castration: in men testosterone, in women oestrogen suppression to the postmenopausal range.
Bewijsbasis
Hoogste bewijs
Humane studie
Humane RCT
Studies
4
4
waarvan bij mensen
1
4
Geregistreerde effecten
4
3
Openstaande tegenstrijdigheden
1
0
Gedocumenteerde bijwerkingen
0
3
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between LL-37 and Triptorelin?
- LL-37 is classified as "Onderzoek (overig)", while Triptorelin is classified as "Onderzoek (overig)". LL-37: LL-37 is the only known human cathelicidin, a 37-amino-acid antimicrobial peptide generated by cleavage of the precursor protein hCAP18. In research it plays a central role in innate immune defence and wound healing, yet acts in a context-dependent manner as both anti- and pro-inflammatory and has been linked to autoimmune processes. LL-37 is not an approved drug; the evidence base is predominantly basic and preclinical. Triptorelin: Synthetic decapeptide GnRH agonist with increased affinity over native gonadotropin-releasing hormone. FDA- and EMA-approved since the 1980s for prostate cancer, endometriosis and precocious puberty. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, LL-37 or Triptorelin?
- The highest available evidence level is "Humane studie" for LL-37 and "Humane RCT" for Triptorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of LL-37 and Triptorelin in Germany and the United States?
- Duitsland: LL-37 — Alleen onderzoek, Triptorelin — Op recept. Verenigde Staten: LL-37 — Alleen onderzoek, Triptorelin — Op recept. These are factual summaries with source and review date on the individual pages.