Vergelijking
Melanotan II vs. Plecanatid
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
121062-08-6
467426-54-6
Molecuulmassa
1024.18 g/mol
1682 g/mol
Halfwaardetijd
1 h
geen gegevens
Sequentie
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2geen gegevens
Werkingsmechanisme
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Plecanatid
Plecanatide is structurally analogous to the body's own uroguanylin and, like it, activates the GC-C receptor at the gut surface, raising cGMP and fluid secretion. Its pH-dependent activity shifts the effect toward the proximal small intestine.
Bewijsbasis
Hoogste bewijs
Humane studie
Humane RCT
Studies
9
0
waarvan bij mensen
5
0
Geregistreerde effecten
4
2
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
6
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Melanotan II and Plecanatid?
- Melanotan II is classified as "Onderzoek (overig)", while Plecanatid is classified as "Onderzoek (overig)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Plecanatid: Plecanatide is a 16-amino-acid analog of the body's own uroguanylin and a guanylate cyclase-C (GC-C) agonist. It is approved for chronic idiopathic constipation (CIC) and IBS with constipation (IBS-C). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Melanotan II or Plecanatid?
- The highest available evidence level is "Humane studie" for Melanotan II and "Humane RCT" for Plecanatid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Melanotan II and Plecanatid in Germany and the United States?
- Duitsland: Melanotan II — Niet goedgekeurd, Plecanatid — Niet goedgekeurd. Verenigde Staten: Melanotan II — Niet goedgekeurd, Plecanatid — Op recept. These are factual summaries with source and review date on the individual pages.