Vergelijking
Melanotan II vs. Triptorelin
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
121062-08-6
57773-63-4
Molecuulmassa
1024.18 g/mol
1311.45 g/mol
Halfwaardetijd
1 h
3 h
Sequentie
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2Werkingsmechanisme
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Triptorelin
Triptorelin binds with high affinity to the GnRH receptor in the pituitary. After initial stimulation of LH and FSH secretion (flare phase, about 1-2 weeks), receptor desensitisation follows with consecutive gonadotropin suppression. This results in a reversible chemical castration: in men testosterone, in women oestrogen suppression to the postmenopausal range.
Bewijsbasis
Hoogste bewijs
Humane studie
Humane RCT
Studies
9
4
waarvan bij mensen
5
4
Geregistreerde effecten
4
3
Openstaande tegenstrijdigheden
1
0
Gedocumenteerde bijwerkingen
6
3
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Melanotan II and Triptorelin?
- Melanotan II is classified as "Onderzoek (overig)", while Triptorelin is classified as "Onderzoek (overig)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Triptorelin: Synthetic decapeptide GnRH agonist with increased affinity over native gonadotropin-releasing hormone. FDA- and EMA-approved since the 1980s for prostate cancer, endometriosis and precocious puberty. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Melanotan II or Triptorelin?
- The highest available evidence level is "Humane studie" for Melanotan II and "Humane RCT" for Triptorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Melanotan II and Triptorelin in Germany and the United States?
- Duitsland: Melanotan II — Niet goedgekeurd, Triptorelin — Op recept. Verenigde Staten: Melanotan II — Niet goedgekeurd, Triptorelin — Op recept. These are factual summaries with source and review date on the individual pages.