Vergelijking
Mod GRF (1-29) vs. Sermorelin
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Groei
Groei
CAS-nr.
863288-34-0
86168-78-7
Molecuulmassa
3367.9 g/mol
3358 g/mol
Halfwaardetijd
0.5 h
0.2 h
Sequentie
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2YADAIFTNSYRKVLGQLSARKLLQDIMSRWerkingsmechanisme
Mod GRF (1-29)
Synthetic analogue of the first 29 amino acids of growth-hormone-releasing hormone (GHRH 1-29). Four amino-acid substitutions (D-Ala at position 2, Gln at 8, Ala at 15, Leu at 27) are intended to slow degradation by dipeptidyl peptidase-IV and increase enzymatic stability relative to native GHRH. Like the native hormone and sermorelin, it binds the GHRH receptor on somatotroph cells of the anterior pituitary; mechanistically this is expected to stimulate endogenous growth-hormone release. Unlike the DAC-conjugated CJC-1295 variant, it lacks albumin binding, so its duration of action remains short.
Sermorelin
Synthetic analogue of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). Stimulates pulsatile endogenous growth-hormone secretion from the pituitary via the GHRH receptor. Very short plasma half-life — pharmacodynamic effect lasts several hours nevertheless.
Bewijsbasis
Hoogste bewijs
Humane studie
Humane RCT
Studies
4
5
waarvan bij mensen
4
3
Geregistreerde effecten
3
3
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
0
3
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Mod GRF (1-29) and Sermorelin?
- Mod GRF (1-29) is classified as "Groei", while Sermorelin is classified as "Groei". Mod GRF (1-29): Tetrasubstituted synthetic analogue of GHRH(1-29), traded on the grey market as "CJC-1295 without DAC". Closely related to sermorelin (GHRH 1-29); a short-acting growth-hormone-releasing-hormone analogue often combined with a GHRP/ghrelin mimetic. Not approved as a medicinal product. Direct human trials of this exact analogue are essentially absent; the factual basis relies on related GHRH(1-29) analogues. Sermorelin: Synthetic analogue of the first 29 amino acids of human GHRH. Stimulates pulsatile growth-hormone secretion from the pituitary. Formerly FDA-approved as Geref Diagnostic, now withdrawn in many markets — compounding and research use dominate. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Mod GRF (1-29) or Sermorelin?
- The highest available evidence level is "Humane studie" for Mod GRF (1-29) and "Humane RCT" for Sermorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Mod GRF (1-29) and Sermorelin in Germany and the United States?
- Duitsland: Mod GRF (1-29) — Niet goedgekeurd, Sermorelin — Niet goedgekeurd. Verenigde Staten: Mod GRF (1-29) — Alleen onderzoek, Sermorelin — Alleen onderzoek. These are factual summaries with source and review date on the individual pages.