Vergelijking

Nafarelin vs. Sincalide

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

geen gegevens

25126-32-3

Molecuulmassa

geen gegevens

1143.29 g/mol

Halfwaardetijd

geen gegevens

Sequentie

geen gegevens

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Werkingsmechanisme

Nafarelin

Nafarelin is a potent GnRH agonist: after an initial stimulation ('flare'), continuous receptor occupancy leads to downregulation and thereby suppression of LH, FSH and the downstream sex hormones.

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Bewijsbasis

Hoogste bewijs

Humane RCT

Humane studie

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Nafarelin	Sincalide
Duitsland	Op recept	Onduidelijk
Verenigde Staten	Op recept	Op recept

Volledige vermeldingen

Nafarelin

Volledige vermelding →

Sincalide

Volledige vermelding →

Frequently asked questions

What is the difference between Nafarelin and Sincalide?: Nafarelin is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Nafarelin: Nafarelin is a GnRH agonist and the only member of this class delivered as a nasal spray. It is approved for treating endometriosis and central precocious puberty. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Nafarelin or Sincalide?: The highest available evidence level is "Humane RCT" for Nafarelin and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Nafarelin and Sincalide in Germany and the United States?: Duitsland: Nafarelin — Op recept, Sincalide — Onduidelijk. Verenigde Staten: Nafarelin — Op recept, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Nafarelin

Sincalide

Duitsland

Op recept

Onduidelijk

Verenigde Staten

Op recept

Frequently asked questions

What is the difference between Nafarelin and Sincalide?

Nafarelin is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Nafarelin: Nafarelin is a GnRH agonist and the only member of this class delivered as a nasal spray. It is approved for treating endometriosis and central precocious puberty. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Nafarelin or Sincalide?

The highest available evidence level is "Humane RCT" for Nafarelin and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Nafarelin and Sincalide in Germany and the United States?

Duitsland: Nafarelin — Op recept, Sincalide — Onduidelijk. Verenigde Staten: Nafarelin — Op recept, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.