Vergelijking

Nafarelin vs. Triptorelin

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

geen gegevens

57773-63-4

Molecuulmassa

geen gegevens

1311.45 g/mol

Halfwaardetijd

geen gegevens

3 h

Sequentie

geen gegevens

pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2

Werkingsmechanisme

Nafarelin

Nafarelin is a potent GnRH agonist: after an initial stimulation ('flare'), continuous receptor occupancy leads to downregulation and thereby suppression of LH, FSH and the downstream sex hormones.

Triptorelin

Triptorelin binds with high affinity to the GnRH receptor in the pituitary. After initial stimulation of LH and FSH secretion (flare phase, about 1-2 weeks), receptor desensitisation follows with consecutive gonadotropin suppression. This results in a reversible chemical castration: in men testosterone, in women oestrogen suppression to the postmenopausal range.

Bewijsbasis

Hoogste bewijs

Humane RCT

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Nafarelin	Triptorelin
Duitsland	Op recept	Op recept
Verenigde Staten	Op recept	Op recept

Volledige vermeldingen

Nafarelin

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Triptorelin

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Frequently asked questions

What is the difference between Nafarelin and Triptorelin?: Nafarelin is classified as "Onderzoek (overig)", while Triptorelin is classified as "Onderzoek (overig)". Nafarelin: Nafarelin is a GnRH agonist and the only member of this class delivered as a nasal spray. It is approved for treating endometriosis and central precocious puberty. Triptorelin: Synthetic decapeptide GnRH agonist with increased affinity over native gonadotropin-releasing hormone. FDA- and EMA-approved since the 1980s for prostate cancer, endometriosis and precocious puberty. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Nafarelin or Triptorelin?: The highest available evidence level is "Humane RCT" for Nafarelin and "Humane RCT" for Triptorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Nafarelin and Triptorelin in Germany and the United States?: Duitsland: Nafarelin — Op recept, Triptorelin — Op recept. Verenigde Staten: Nafarelin — Op recept, Triptorelin — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Nafarelin

Triptorelin

Duitsland

Op recept

Verenigde Staten

Op recept

Frequently asked questions

What is the difference between Nafarelin and Triptorelin?

Nafarelin is classified as "Onderzoek (overig)", while Triptorelin is classified as "Onderzoek (overig)". Nafarelin: Nafarelin is a GnRH agonist and the only member of this class delivered as a nasal spray. It is approved for treating endometriosis and central precocious puberty. Triptorelin: Synthetic decapeptide GnRH agonist with increased affinity over native gonadotropin-releasing hormone. FDA- and EMA-approved since the 1980s for prostate cancer, endometriosis and precocious puberty. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Nafarelin or Triptorelin?

The highest available evidence level is "Humane RCT" for Nafarelin and "Humane RCT" for Triptorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Nafarelin and Triptorelin in Germany and the United States?

Duitsland: Nafarelin — Op recept, Triptorelin — Op recept. Verenigde Staten: Nafarelin — Op recept, Triptorelin — Op recept. These are factual summaries with source and review date on the individual pages.