Vergelijking
Octreotide vs. Sekretin
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
83150-76-9
geen gegevens
Molecuulmassa
1019.24 g/mol
3055.5 g/mol
Halfwaardetijd
1.7 h
geen gegevens
Sequentie
D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr(ol)geen gegevens
Werkingsmechanisme
Octreotide
Octreotide is a cyclic octapeptide that selectively binds somatostatin-receptor subtypes SSTR2 and SSTR5. Via G-protein-coupled signalling, adenylyl cyclase is inhibited, reducing the secretion of multiple hormones (growth hormone, IGF-1, glucagon, insulin, VIP, serotonin). Structural stabilisation via a disulfide bridge and D-amino acids extends the half-life relative to natural somatostatin (minutes to several hours).
Sekretin
Secretin binds the Gs-coupled secretin receptor (SCTR) on pancreatic duct cells, opens CFTR chloride channels and triggers secretion of bicarbonate-rich pancreatic fluid and bile flow.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane studie
Studies
5
0
waarvan bij mensen
4
0
Geregistreerde effecten
3
2
Openstaande tegenstrijdigheden
1
0
Gedocumenteerde bijwerkingen
2
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Octreotide and Sekretin?
- Octreotide is classified as "Onderzoek (overig)", while Sekretin is classified as "Onderzoek (overig)". Octreotide: Synthetic octapeptide somatostatin analog with a longer half-life than endogenous somatostatin. FDA- and EMA-approved since the 1980s for acromegaly and neuroendocrine tumours. Sekretin: Secretin is a 27-amino-acid hormone that regulates pancreatic bicarbonate secretion. As ChiRhoStim it is FDA-approved as a diagnostic agent (pancreatic function test, gastrinoma test, secretin-enhanced MRCP). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Octreotide or Sekretin?
- The highest available evidence level is "Humane RCT" for Octreotide and "Humane studie" for Sekretin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Octreotide and Sekretin in Germany and the United States?
- Duitsland: Octreotide — Op recept, Sekretin — Op recept. Verenigde Staten: Octreotide — Op recept, Sekretin — Op recept. These are factual summaries with source and review date on the individual pages.