Сравнение
Cagrilintide vs. Pramlintid
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Метаболизм
Метаболизм
Номер CAS
1415456-99-3
151126-32-8
Молекулярная масса
4253.7 g/mol
3949.4 g/mol
Период полувыведения
168 h
нет данных
Последовательность
KCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTYнет данных
Механизм действия
Cagrilintide
Cagrilintide binds amylin receptors (AMY1, AMY3, formed by the calcitonin receptor plus RAMP proteins). Activation delays gastric emptying, inhibits postprandial glucagon secretion and modulates central satiety signalling via area postrema neurons. An acyl modification enables albumin binding and thereby weekly dosing.
Pramlintid
Pramlintide mimics the beta-cell hormone amylin, which is co-secreted with insulin. It slows gastric emptying, suppresses postprandial glucagon release and promotes satiety — thereby blunting post-meal blood-glucose spikes.
Доказательная база
Наивысшая доказательность
РКИ на людях
РКИ на людях
Исследования
4
0
из них на людях
3
0
Зафиксированные эффекты
3
2
Открытые противоречия
1
1
Задокументированные нежелательные явления
1
2
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Cagrilintide and Pramlintid?
- Cagrilintide is classified as "Метаболизм", while Pramlintid is classified as "Метаболизм". Cagrilintide: Synthetic long-acting amylin analog being developed in combination with semaglutide (CagriSema). Phase 3 trials for obesity and type 2 diabetes are ongoing. No marketing approval yet. Pramlintid: Pramlintide is a synthetic analog of the hormone amylin. It is used as an adjunct to mealtime insulin therapy in type 1 and type 2 diabetes and, among other things, slows gastric emptying. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Cagrilintide or Pramlintid?
- The highest available evidence level is "РКИ на людях" for Cagrilintide and "РКИ на людях" for Pramlintid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Cagrilintide and Pramlintid in Germany and the United States?
- Германия: Cagrilintide — Не одобрено, Pramlintid — Не одобрено. США: Cagrilintide — Не одобрено, Pramlintid — Рецептурный. These are factual summaries with source and review date on the individual pages.