Vergelijking
Cagrilintide vs. Pramlintid
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Metabool
Metabool
CAS-nr.
1415456-99-3
151126-32-8
Molecuulmassa
4253.7 g/mol
3949.4 g/mol
Halfwaardetijd
168 h
geen gegevens
Sequentie
KCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTYgeen gegevens
Werkingsmechanisme
Cagrilintide
Cagrilintide binds amylin receptors (AMY1, AMY3, formed by the calcitonin receptor plus RAMP proteins). Activation delays gastric emptying, inhibits postprandial glucagon secretion and modulates central satiety signalling via area postrema neurons. An acyl modification enables albumin binding and thereby weekly dosing.
Pramlintid
Pramlintide mimics the beta-cell hormone amylin, which is co-secreted with insulin. It slows gastric emptying, suppresses postprandial glucagon release and promotes satiety — thereby blunting post-meal blood-glucose spikes.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane RCT
Studies
4
0
waarvan bij mensen
3
0
Geregistreerde effecten
3
2
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
1
2
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Cagrilintide and Pramlintid?
- Cagrilintide is classified as "Metabool", while Pramlintid is classified as "Metabool". Cagrilintide: Synthetic long-acting amylin analog being developed in combination with semaglutide (CagriSema). Phase 3 trials for obesity and type 2 diabetes are ongoing. No marketing approval yet. Pramlintid: Pramlintide is a synthetic analog of the hormone amylin. It is used as an adjunct to mealtime insulin therapy in type 1 and type 2 diabetes and, among other things, slows gastric emptying. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Cagrilintide or Pramlintid?
- The highest available evidence level is "Humane RCT" for Cagrilintide and "Humane RCT" for Pramlintid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Cagrilintide and Pramlintid in Germany and the United States?
- Duitsland: Cagrilintide — Niet goedgekeurd, Pramlintid — Niet goedgekeurd. Verenigde Staten: Cagrilintide — Niet goedgekeurd, Pramlintid — Op recept. These are factual summaries with source and review date on the individual pages.