Сравнение
Dulaglutide vs. Liraglutide
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Метаболизм
Метаболизм
Номер CAS
923950-08-7
204656-20-2
Молекулярная масса
59670 g/mol
3751 g/mol
Период полувыведения
110 h
13 h
Последовательность
GLP-1(7-37)-Variante kovalent verbunden mit modifiziertem humanen IgG4-FcHAEGTFTSDVSSYLEGQAAKEFIAWLVRGRGМеханизм действия
Dulaglutide
Dulaglutide consists of two modified GLP-1(7-37) sequences covalently linked to a human IgG4-Fc. The Fc fusion increases molecular weight substantially (~60 kDa), reduces renal filtration and extends the half-life to several days. GLP-1 receptor activation glucose-dependently stimulates insulin secretion, inhibits glucagon, delays gastric emptying and modulates central satiety signalling.
Liraglutide
Liraglutide is a synthetic GLP-1 analog with 97% sequence identity to human GLP-1. A fatty-acid side chain (C16) on Lys-26 reversibly binds serum albumin and protects against DPP-4 degradation. GLP-1 receptor activation glucose-dependently stimulates insulin secretion, inhibits glucagon secretion, delays gastric emptying and modulates central satiety.
Доказательная база
Наивысшая доказательность
РКИ на людях
РКИ на людях
Исследования
5
5
из них на людях
5
4
Зафиксированные эффекты
3
3
Открытые противоречия
1
1
Задокументированные нежелательные явления
2
1
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Dulaglutide and Liraglutide?
- Dulaglutide is classified as "Метаболизм", while Liraglutide is classified as "Метаболизм". Dulaglutide: GLP-1 receptor agonist designed as a fusion protein of two modified GLP-1(7-37) sequences covalently linked to a human IgG4-Fc fragment. FDA-approved 2014 (Trulicity) for type 2 diabetes; EMA approval 2014. Liraglutide: GLP-1 receptor agonist with a half-life of about 13 hours. The first daily (not weekly) modern GLP-1 RA — approved as Victoza for type 2 diabetes (2010) and Saxenda for obesity (2014). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Dulaglutide or Liraglutide?
- The highest available evidence level is "РКИ на людях" for Dulaglutide and "РКИ на людях" for Liraglutide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Dulaglutide and Liraglutide in Germany and the United States?
- Германия: Dulaglutide — Рецептурный, Liraglutide — Рецептурный. США: Dulaglutide — Рецептурный, Liraglutide — Рецептурный. These are factual summaries with source and review date on the individual pages.