Confronto
Dulaglutide vs. Liraglutide
Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.
Identità
Categoria
Metabolico
Metabolico
N. CAS
923950-08-7
204656-20-2
Peso molecolare
59670 g/mol
3751 g/mol
Emivita
110 h
13 h
Sequenza
GLP-1(7-37)-Variante kovalent verbunden mit modifiziertem humanen IgG4-FcHAEGTFTSDVSSYLEGQAAKEFIAWLVRGRGMeccanismo d'azione
Dulaglutide
Dulaglutide consists of two modified GLP-1(7-37) sequences covalently linked to a human IgG4-Fc. The Fc fusion increases molecular weight substantially (~60 kDa), reduces renal filtration and extends the half-life to several days. GLP-1 receptor activation glucose-dependently stimulates insulin secretion, inhibits glucagon, delays gastric emptying and modulates central satiety signalling.
Liraglutide
Liraglutide is a synthetic GLP-1 analog with 97% sequence identity to human GLP-1. A fatty-acid side chain (C16) on Lys-26 reversibly binds serum albumin and protects against DPP-4 degradation. GLP-1 receptor activation glucose-dependently stimulates insulin secretion, inhibits glucagon secretion, delays gastric emptying and modulates central satiety.
Base di evidenze
Evidenza più alta
RCT sull'uomo
RCT sull'uomo
Studi
5
5
di cui sull'uomo
5
4
Effetti registrati
3
3
Contraddizioni aperte
1
1
Eventi avversi documentati
2
1
Stato legale
Voci complete
Frequently asked questions
- What is the difference between Dulaglutide and Liraglutide?
- Dulaglutide is classified as "Metabolico", while Liraglutide is classified as "Metabolico". Dulaglutide: GLP-1 receptor agonist designed as a fusion protein of two modified GLP-1(7-37) sequences covalently linked to a human IgG4-Fc fragment. FDA-approved 2014 (Trulicity) for type 2 diabetes; EMA approval 2014. Liraglutide: GLP-1 receptor agonist with a half-life of about 13 hours. The first daily (not weekly) modern GLP-1 RA — approved as Victoza for type 2 diabetes (2010) and Saxenda for obesity (2014). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Dulaglutide or Liraglutide?
- The highest available evidence level is "RCT sull'uomo" for Dulaglutide and "RCT sull'uomo" for Liraglutide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Dulaglutide and Liraglutide in Germany and the United States?
- Germania: Dulaglutide — Su prescrizione, Liraglutide — Su prescrizione. Stati Uniti: Dulaglutide — Su prescrizione, Liraglutide — Su prescrizione. These are factual summaries with source and review date on the individual pages.