Comparison

Dulaglutide vs. Liraglutide

Two peptides side-by-side — identity, evidence base, legal status and known adverse events.

Identity

Mechanism of action

Dulaglutide

Dulaglutide consists of two modified GLP-1(7-37) sequences covalently linked to a human IgG4-Fc. The Fc fusion increases molecular weight substantially (~60 kDa), reduces renal filtration and extends the half-life to several days. GLP-1 receptor activation glucose-dependently stimulates insulin secretion, inhibits glucagon, delays gastric emptying and modulates central satiety signalling.

Liraglutide

Liraglutide is a synthetic GLP-1 analog with 97% sequence identity to human GLP-1. A fatty-acid side chain (C16) on Lys-26 reversibly binds serum albumin and protects against DPP-4 degradation. GLP-1 receptor activation glucose-dependently stimulates insulin secretion, inhibits glucagon secretion, delays gastric emptying and modulates central satiety.

Evidence base

Highest evidence

Human RCT

Studies

of which in humans

Effects recorded

Open conflicts

Documented adverse events

Legal status

Country	Dulaglutide	Liraglutide
Germany	Prescription	Prescription
JP	Prescription	—
United States	Prescription	Prescription

Full entries

Frequently asked questions

What is the difference between Dulaglutide and Liraglutide?: Dulaglutide is classified as "Metabolic", while Liraglutide is classified as "Metabolic". Dulaglutide: GLP-1 receptor agonist designed as a fusion protein of two modified GLP-1(7-37) sequences covalently linked to a human IgG4-Fc fragment. FDA-approved 2014 (Trulicity) for type 2 diabetes; EMA approval 2014. Liraglutide: GLP-1 receptor agonist with a half-life of about 13 hours. The first daily (not weekly) modern GLP-1 RA — approved as Victoza for type 2 diabetes (2010) and Saxenda for obesity (2014). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Dulaglutide or Liraglutide?: The highest available evidence level is "Human RCT" for Dulaglutide and "Human RCT" for Liraglutide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Dulaglutide and Liraglutide in Germany and the United States?: Germany: Dulaglutide — Prescription, Liraglutide — Prescription. United States: Dulaglutide — Prescription, Liraglutide — Prescription. These are factual summaries with source and review date on the individual pages.

Country

Dulaglutide

Liraglutide

Germany

Prescription

—

United States

Prescription

Frequently asked questions

What is the difference between Dulaglutide and Liraglutide?

Dulaglutide is classified as "Metabolic", while Liraglutide is classified as "Metabolic". Dulaglutide: GLP-1 receptor agonist designed as a fusion protein of two modified GLP-1(7-37) sequences covalently linked to a human IgG4-Fc fragment. FDA-approved 2014 (Trulicity) for type 2 diabetes; EMA approval 2014. Liraglutide: GLP-1 receptor agonist with a half-life of about 13 hours. The first daily (not weekly) modern GLP-1 RA — approved as Victoza for type 2 diabetes (2010) and Saxenda for obesity (2014). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Dulaglutide or Liraglutide?

The highest available evidence level is "Human RCT" for Dulaglutide and "Human RCT" for Liraglutide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Dulaglutide and Liraglutide in Germany and the United States?

Germany: Dulaglutide — Prescription, Liraglutide — Prescription. United States: Dulaglutide — Prescription, Liraglutide — Prescription. These are factual summaries with source and review date on the individual pages.