Сравнение

Epitalon vs. Sincalide

Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.

Идентичность

Категория

Исследования (прочее)

Номер CAS

307297-39-8

25126-32-3

Молекулярная масса

390.35 g/mol

1143.29 g/mol

Период полувыведения

0.3 h

нет данных

Последовательность

Ala-Glu-Asp-Gly

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Механизм действия

Epitalon

Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Доказательная база

Наивысшая доказательность

Исследование на людях

Исследования

из них на людях

Зафиксированные эффекты

Открытые противоречия

Задокументированные нежелательные явления

Правовой статус

Country	Epitalon	Sincalide
Германия	Не одобрено	Неясно
RU	Только для исследований	—
США	Не одобрено	Рецептурный

Полные записи

Frequently asked questions

What is the difference between Epitalon and Sincalide?: Epitalon is classified as "Исследования (прочее)", while Sincalide is classified as "Исследования (прочее)". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Epitalon or Sincalide?: The highest available evidence level is "Исследование на людях" for Epitalon and "Исследование на людях" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Epitalon and Sincalide in Germany and the United States?: Германия: Epitalon — Не одобрено, Sincalide — Неясно. США: Epitalon — Не одобрено, Sincalide — Рецептурный. These are factual summaries with source and review date on the individual pages.

Country

Epitalon

Sincalide

Германия

Не одобрено

Неясно

Только для исследований

—

США

Не одобрено

Рецептурный

Frequently asked questions

What is the difference between Epitalon and Sincalide?

Epitalon is classified as "Исследования (прочее)", while Sincalide is classified as "Исследования (прочее)". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Epitalon or Sincalide?

The highest available evidence level is "Исследование на людях" for Epitalon and "Исследование на людях" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Epitalon and Sincalide in Germany and the United States?

Германия: Epitalon — Не одобрено, Sincalide — Неясно. США: Epitalon — Не одобрено, Sincalide — Рецептурный. These are factual summaries with source and review date on the individual pages.