Vergelijking

Epitalon vs. Sincalide

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

307297-39-8

25126-32-3

Molecuulmassa

390.35 g/mol

1143.29 g/mol

Halfwaardetijd

0.3 h

geen gegevens

Sequentie

Ala-Glu-Asp-Gly

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Werkingsmechanisme

Epitalon

Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Bewijsbasis

Hoogste bewijs

Humane studie

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Epitalon	Sincalide
Duitsland	Niet goedgekeurd	Onduidelijk
RU	Alleen onderzoek	—
Verenigde Staten	Niet goedgekeurd	Op recept

Volledige vermeldingen

Epitalon

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Sincalide

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Frequently asked questions

What is the difference between Epitalon and Sincalide?: Epitalon is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Epitalon or Sincalide?: The highest available evidence level is "Humane studie" for Epitalon and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Epitalon and Sincalide in Germany and the United States?: Duitsland: Epitalon — Niet goedgekeurd, Sincalide — Onduidelijk. Verenigde Staten: Epitalon — Niet goedgekeurd, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Epitalon

Sincalide

Duitsland

Niet goedgekeurd

Onduidelijk

Alleen onderzoek

—

Verenigde Staten

Niet goedgekeurd

Op recept

Frequently asked questions

What is the difference between Epitalon and Sincalide?

Epitalon is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Epitalon or Sincalide?

The highest available evidence level is "Humane studie" for Epitalon and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Epitalon and Sincalide in Germany and the United States?

Duitsland: Epitalon — Niet goedgekeurd, Sincalide — Onduidelijk. Verenigde Staten: Epitalon — Niet goedgekeurd, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.