Confronto

Epitalon vs. Sincalide

Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.

Identità

Categoria

Ricerca (altro)

N. CAS

307297-39-8

25126-32-3

Peso molecolare

390.35 g/mol

1143.29 g/mol

Emivita

0.3 h

nessun dato

Sequenza

Ala-Glu-Asp-Gly

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Meccanismo d'azione

Epitalon

Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Base di evidenze

Evidenza più alta

Studio sull'uomo

Studi

di cui sull'uomo

Effetti registrati

Contraddizioni aperte

Eventi avversi documentati

Stato legale

Country	Epitalon	Sincalide
Germania	Non approvato	Non chiaro
RU	Solo ricerca	—
Stati Uniti	Non approvato	Su prescrizione

Voci complete

Frequently asked questions

What is the difference between Epitalon and Sincalide?: Epitalon is classified as "Ricerca (altro)", while Sincalide is classified as "Ricerca (altro)". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Epitalon or Sincalide?: The highest available evidence level is "Studio sull'uomo" for Epitalon and "Studio sull'uomo" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Epitalon and Sincalide in Germany and the United States?: Germania: Epitalon — Non approvato, Sincalide — Non chiaro. Stati Uniti: Epitalon — Non approvato, Sincalide — Su prescrizione. These are factual summaries with source and review date on the individual pages.

Country

Epitalon

Sincalide

Germania

Non approvato

Non chiaro

Solo ricerca

—

Stati Uniti

Non approvato

Su prescrizione

Frequently asked questions

What is the difference between Epitalon and Sincalide?

Epitalon is classified as "Ricerca (altro)", while Sincalide is classified as "Ricerca (altro)". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Epitalon or Sincalide?

The highest available evidence level is "Studio sull'uomo" for Epitalon and "Studio sull'uomo" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Epitalon and Sincalide in Germany and the United States?

Germania: Epitalon — Non approvato, Sincalide — Non chiaro. Stati Uniti: Epitalon — Non approvato, Sincalide — Su prescrizione. These are factual summaries with source and review date on the individual pages.