Сравнение
Melanotan II vs. Selank
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Исследования (прочее)
Исследования (прочее)
Номер CAS
121062-08-6
129954-34-3
Молекулярная масса
1024.18 g/mol
751.85 g/mol
Период полувыведения
1 h
0.3 h
Последовательность
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2Thr-Lys-Pro-Arg-Pro-Gly-ProМеханизм действия
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Selank
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
Доказательная база
Наивысшая доказательность
Исследование на людях
Исследование на людях
Исследования
9
4
из них на людях
5
2
Зафиксированные эффекты
4
3
Открытые противоречия
1
1
Задокументированные нежелательные явления
6
1
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Melanotan II and Selank?
- Melanotan II is classified as "Исследования (прочее)", while Selank is classified as "Исследования (прочее)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Selank: Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trials are absent; efficacy assessment relies on Russian research literature. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Melanotan II or Selank?
- The highest available evidence level is "Исследование на людях" for Melanotan II and "Исследование на людях" for Selank. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Melanotan II and Selank in Germany and the United States?
- Германия: Melanotan II — Не одобрено, Selank — Не одобрено. США: Melanotan II — Не одобрено, Selank — Не одобрено. These are factual summaries with source and review date on the individual pages.