Vergelijking

Melanotan II vs. Selank

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

121062-08-6

129954-34-3

Molecuulmassa

1024.18 g/mol

751.85 g/mol

Halfwaardetijd

1 h

0.3 h

Sequentie

Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Thr-Lys-Pro-Arg-Pro-Gly-Pro

Werkingsmechanisme

Melanotan II

Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.

Selank

Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.

Bewijsbasis

Hoogste bewijs

Humane studie

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Melanotan II	Selank
Australië	Verboden	—
Duitsland	Niet goedgekeurd	Niet goedgekeurd
Verenigd Koninkrijk	Verboden	—
RU	—	Op recept
Verenigde Staten	Niet goedgekeurd	Niet goedgekeurd

Volledige vermeldingen

Melanotan II

Volledige vermelding →

Selank

Volledige vermelding →

Frequently asked questions

What is the difference between Melanotan II and Selank?: Melanotan II is classified as "Onderzoek (overig)", while Selank is classified as "Onderzoek (overig)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Selank: Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trials are absent; efficacy assessment relies on Russian research literature. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Melanotan II or Selank?: The highest available evidence level is "Humane studie" for Melanotan II and "Humane studie" for Selank. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Melanotan II and Selank in Germany and the United States?: Duitsland: Melanotan II — Niet goedgekeurd, Selank — Niet goedgekeurd. Verenigde Staten: Melanotan II — Niet goedgekeurd, Selank — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.

Country

Melanotan II

Selank

Australië

Verboden

—

Duitsland

Niet goedgekeurd

Verenigd Koninkrijk

Verboden

—

Op recept

Verenigde Staten

Niet goedgekeurd

Frequently asked questions

What is the difference between Melanotan II and Selank?

Melanotan II is classified as "Onderzoek (overig)", while Selank is classified as "Onderzoek (overig)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Selank: Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trials are absent; efficacy assessment relies on Russian research literature. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Melanotan II or Selank?

The highest available evidence level is "Humane studie" for Melanotan II and "Humane studie" for Selank. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Melanotan II and Selank in Germany and the United States?

Duitsland: Melanotan II — Niet goedgekeurd, Selank — Niet goedgekeurd. Verenigde Staten: Melanotan II — Niet goedgekeurd, Selank — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.