Confronto

Melanotan II vs. Selank

Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.

Identità

Categoria

Ricerca (altro)

N. CAS

121062-08-6

129954-34-3

Peso molecolare

1024.18 g/mol

751.85 g/mol

Emivita

1 h

0.3 h

Sequenza

Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Thr-Lys-Pro-Arg-Pro-Gly-Pro

Meccanismo d'azione

Melanotan II

Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.

Selank

Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.

Base di evidenze

Evidenza più alta

Studio sull'uomo

Studi

di cui sull'uomo

Effetti registrati

Contraddizioni aperte

Eventi avversi documentati

Stato legale

Country	Melanotan II	Selank
Australia	Vietato	—
Germania	Non approvato	Non approvato
Regno Unito	Vietato	—
RU	—	Su prescrizione
Stati Uniti	Non approvato	Non approvato

Voci complete

Frequently asked questions

What is the difference between Melanotan II and Selank?: Melanotan II is classified as "Ricerca (altro)", while Selank is classified as "Ricerca (altro)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Selank: Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trials are absent; efficacy assessment relies on Russian research literature. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Melanotan II or Selank?: The highest available evidence level is "Studio sull'uomo" for Melanotan II and "Studio sull'uomo" for Selank. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Melanotan II and Selank in Germany and the United States?: Germania: Melanotan II — Non approvato, Selank — Non approvato. Stati Uniti: Melanotan II — Non approvato, Selank — Non approvato. These are factual summaries with source and review date on the individual pages.

Country

Melanotan II

Selank

Australia

Vietato

—

Germania

Non approvato

Regno Unito

Vietato

—

Su prescrizione

Stati Uniti

Non approvato

Frequently asked questions

What is the difference between Melanotan II and Selank?

Melanotan II is classified as "Ricerca (altro)", while Selank is classified as "Ricerca (altro)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Selank: Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trials are absent; efficacy assessment relies on Russian research literature. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Melanotan II or Selank?

The highest available evidence level is "Studio sull'uomo" for Melanotan II and "Studio sull'uomo" for Selank. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Melanotan II and Selank in Germany and the United States?

Germania: Melanotan II — Non approvato, Selank — Non approvato. Stati Uniti: Melanotan II — Non approvato, Selank — Non approvato. These are factual summaries with source and review date on the individual pages.