Сравнение

Melanotan II vs. Sincalide

Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.

Идентичность

Категория

Исследования (прочее)

Номер CAS

121062-08-6

25126-32-3

Молекулярная масса

1024.18 g/mol

1143.29 g/mol

Период полувыведения

1 h

нет данных

Последовательность

Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Механизм действия

Melanotan II

Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Доказательная база

Наивысшая доказательность

Исследование на людях

Исследования

из них на людях

Зафиксированные эффекты

Открытые противоречия

Задокументированные нежелательные явления

Правовой статус

Country	Melanotan II	Sincalide
Австралия	Запрещено	—
Германия	Не одобрено	Неясно
Великобритания	Запрещено	—
США	Не одобрено	Рецептурный

Полные записи

Frequently asked questions

What is the difference between Melanotan II and Sincalide?: Melanotan II is classified as "Исследования (прочее)", while Sincalide is classified as "Исследования (прочее)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Melanotan II or Sincalide?: The highest available evidence level is "Исследование на людях" for Melanotan II and "Исследование на людях" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Melanotan II and Sincalide in Germany and the United States?: Германия: Melanotan II — Не одобрено, Sincalide — Неясно. США: Melanotan II — Не одобрено, Sincalide — Рецептурный. These are factual summaries with source and review date on the individual pages.

Country

Melanotan II

Sincalide

Австралия

Запрещено

—

Германия

Не одобрено

Неясно

Великобритания

Запрещено

—

США

Не одобрено

Рецептурный

Frequently asked questions

What is the difference between Melanotan II and Sincalide?

Melanotan II is classified as "Исследования (прочее)", while Sincalide is classified as "Исследования (прочее)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Melanotan II or Sincalide?

The highest available evidence level is "Исследование на людях" for Melanotan II and "Исследование на людях" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Melanotan II and Sincalide in Germany and the United States?

Германия: Melanotan II — Не одобрено, Sincalide — Неясно. США: Melanotan II — Не одобрено, Sincalide — Рецептурный. These are factual summaries with source and review date on the individual pages.