Confronto

Melanotan II vs. Sincalide

Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.

Identità

Categoria

Ricerca (altro)

N. CAS

121062-08-6

25126-32-3

Peso molecolare

1024.18 g/mol

1143.29 g/mol

Emivita

1 h

nessun dato

Sequenza

Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Meccanismo d'azione

Melanotan II

Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Base di evidenze

Evidenza più alta

Studio sull'uomo

Studi

di cui sull'uomo

Effetti registrati

Contraddizioni aperte

Eventi avversi documentati

Stato legale

Country	Melanotan II	Sincalide
Australia	Vietato	—
Germania	Non approvato	Non chiaro
Regno Unito	Vietato	—
Stati Uniti	Non approvato	Su prescrizione

Voci complete

Frequently asked questions

What is the difference between Melanotan II and Sincalide?: Melanotan II is classified as "Ricerca (altro)", while Sincalide is classified as "Ricerca (altro)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Melanotan II or Sincalide?: The highest available evidence level is "Studio sull'uomo" for Melanotan II and "Studio sull'uomo" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Melanotan II and Sincalide in Germany and the United States?: Germania: Melanotan II — Non approvato, Sincalide — Non chiaro. Stati Uniti: Melanotan II — Non approvato, Sincalide — Su prescrizione. These are factual summaries with source and review date on the individual pages.

Country

Melanotan II

Sincalide

Australia

Vietato

—

Germania

Non approvato

Non chiaro

Regno Unito

Vietato

—

Stati Uniti

Non approvato

Su prescrizione

Frequently asked questions

What is the difference between Melanotan II and Sincalide?

Melanotan II is classified as "Ricerca (altro)", while Sincalide is classified as "Ricerca (altro)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Melanotan II or Sincalide?

The highest available evidence level is "Studio sull'uomo" for Melanotan II and "Studio sull'uomo" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Melanotan II and Sincalide in Germany and the United States?

Germania: Melanotan II — Non approvato, Sincalide — Non chiaro. Stati Uniti: Melanotan II — Non approvato, Sincalide — Su prescrizione. These are factual summaries with source and review date on the individual pages.