Vergelijking

Melanotan II vs. Sincalide

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

121062-08-6

25126-32-3

Molecuulmassa

1024.18 g/mol

1143.29 g/mol

Halfwaardetijd

1 h

geen gegevens

Sequentie

Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Werkingsmechanisme

Melanotan II

Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Bewijsbasis

Hoogste bewijs

Humane studie

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Melanotan II	Sincalide
Australië	Verboden	—
Duitsland	Niet goedgekeurd	Onduidelijk
Verenigd Koninkrijk	Verboden	—
Verenigde Staten	Niet goedgekeurd	Op recept

Volledige vermeldingen

Melanotan II

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Sincalide

Volledige vermelding →

Frequently asked questions

What is the difference between Melanotan II and Sincalide?: Melanotan II is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Melanotan II or Sincalide?: The highest available evidence level is "Humane studie" for Melanotan II and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Melanotan II and Sincalide in Germany and the United States?: Duitsland: Melanotan II — Niet goedgekeurd, Sincalide — Onduidelijk. Verenigde Staten: Melanotan II — Niet goedgekeurd, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Melanotan II

Sincalide

Australië

Verboden

—

Duitsland

Niet goedgekeurd

Onduidelijk

Verenigd Koninkrijk

Verboden

—

Verenigde Staten

Niet goedgekeurd

Op recept

Frequently asked questions

What is the difference between Melanotan II and Sincalide?

Melanotan II is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Melanotan II or Sincalide?

The highest available evidence level is "Humane studie" for Melanotan II and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Melanotan II and Sincalide in Germany and the United States?

Duitsland: Melanotan II — Niet goedgekeurd, Sincalide — Onduidelijk. Verenigde Staten: Melanotan II — Niet goedgekeurd, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.