Сравнение

Bremelanotide vs. Sekretin

Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.

Идентичность

Категория

Исследования (прочее)

Номер CAS

189691-06-3

нет данных

Молекулярная масса

1025.18 g/mol

3055.5 g/mol

Период полувыведения

2.7 h

нет данных

Последовательность

Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH

нет данных

Механизм действия

Bremelanotide

Bremelanotide is a cyclic peptide that binds non-selectively to melanocortin receptors (MC1R through MC5R) — with highest affinity at MC4R in the central nervous system. The precise role of MC4R activation in sexual behaviour is not fully understood; animal data show effects on hypothalamic circuits. Peripheral effects (blood pressure, hyperpigmentation) are attributed to MC1R/MC2R.

Sekretin

Secretin binds the Gs-coupled secretin receptor (SCTR) on pancreatic duct cells, opens CFTR chloride channels and triggers secretion of bicarbonate-rich pancreatic fluid and bile flow.

Доказательная база

Наивысшая доказательность

РКИ на людях

Исследование на людях

Исследования

из них на людях

Зафиксированные эффекты

Открытые противоречия

Задокументированные нежелательные явления

Правовой статус

Country	Bremelanotide	Sekretin
Австралия	Ограничено	—
Германия	Не одобрено	Рецептурный
США	Рецептурный	Рецептурный

Полные записи

Frequently asked questions

What is the difference between Bremelanotide and Sekretin?: Bremelanotide is classified as "Исследования (прочее)", while Sekretin is classified as "Исследования (прочее)". Bremelanotide: Synthetic cyclic heptapeptide acting as a non-selective melanocortin-receptor agonist. FDA-approved in 2019 as Vyleesi for hypoactive sexual desire disorder (HSDD) in pre-menopausal women. Sekretin: Secretin is a 27-amino-acid hormone that regulates pancreatic bicarbonate secretion. As ChiRhoStim it is FDA-approved as a diagnostic agent (pancreatic function test, gastrinoma test, secretin-enhanced MRCP). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Bremelanotide or Sekretin?: The highest available evidence level is "РКИ на людях" for Bremelanotide and "Исследование на людях" for Sekretin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Bremelanotide and Sekretin in Germany and the United States?: Германия: Bremelanotide — Не одобрено, Sekretin — Рецептурный. США: Bremelanotide — Рецептурный, Sekretin — Рецептурный. These are factual summaries with source and review date on the individual pages.

Country

Bremelanotide

Sekretin

Австралия

Ограничено

—

Германия

Не одобрено

Рецептурный

США

Рецептурный

Frequently asked questions

What is the difference between Bremelanotide and Sekretin?

Bremelanotide is classified as "Исследования (прочее)", while Sekretin is classified as "Исследования (прочее)". Bremelanotide: Synthetic cyclic heptapeptide acting as a non-selective melanocortin-receptor agonist. FDA-approved in 2019 as Vyleesi for hypoactive sexual desire disorder (HSDD) in pre-menopausal women. Sekretin: Secretin is a 27-amino-acid hormone that regulates pancreatic bicarbonate secretion. As ChiRhoStim it is FDA-approved as a diagnostic agent (pancreatic function test, gastrinoma test, secretin-enhanced MRCP). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Bremelanotide or Sekretin?

The highest available evidence level is "РКИ на людях" for Bremelanotide and "Исследование на людях" for Sekretin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Bremelanotide and Sekretin in Germany and the United States?

Германия: Bremelanotide — Не одобрено, Sekretin — Рецептурный. США: Bremelanotide — Рецептурный, Sekretin — Рецептурный. These are factual summaries with source and review date on the individual pages.