Vergelijking

Bremelanotide vs. Sekretin

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

189691-06-3

geen gegevens

Molecuulmassa

1025.18 g/mol

3055.5 g/mol

Halfwaardetijd

2.7 h

geen gegevens

Sequentie

Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH

geen gegevens

Werkingsmechanisme

Bremelanotide

Bremelanotide is a cyclic peptide that binds non-selectively to melanocortin receptors (MC1R through MC5R) — with highest affinity at MC4R in the central nervous system. The precise role of MC4R activation in sexual behaviour is not fully understood; animal data show effects on hypothalamic circuits. Peripheral effects (blood pressure, hyperpigmentation) are attributed to MC1R/MC2R.

Sekretin

Secretin binds the Gs-coupled secretin receptor (SCTR) on pancreatic duct cells, opens CFTR chloride channels and triggers secretion of bicarbonate-rich pancreatic fluid and bile flow.

Bewijsbasis

Hoogste bewijs

Humane RCT

Humane studie

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Bremelanotide	Sekretin
Australië	Beperkt	—
Duitsland	Niet goedgekeurd	Op recept
Verenigde Staten	Op recept	Op recept

Volledige vermeldingen

Bremelanotide

Volledige vermelding →

Sekretin

Volledige vermelding →

Frequently asked questions

What is the difference between Bremelanotide and Sekretin?: Bremelanotide is classified as "Onderzoek (overig)", while Sekretin is classified as "Onderzoek (overig)". Bremelanotide: Synthetic cyclic heptapeptide acting as a non-selective melanocortin-receptor agonist. FDA-approved in 2019 as Vyleesi for hypoactive sexual desire disorder (HSDD) in pre-menopausal women. Sekretin: Secretin is a 27-amino-acid hormone that regulates pancreatic bicarbonate secretion. As ChiRhoStim it is FDA-approved as a diagnostic agent (pancreatic function test, gastrinoma test, secretin-enhanced MRCP). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Bremelanotide or Sekretin?: The highest available evidence level is "Humane RCT" for Bremelanotide and "Humane studie" for Sekretin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Bremelanotide and Sekretin in Germany and the United States?: Duitsland: Bremelanotide — Niet goedgekeurd, Sekretin — Op recept. Verenigde Staten: Bremelanotide — Op recept, Sekretin — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Bremelanotide

Sekretin

Australië

Beperkt

—

Duitsland

Niet goedgekeurd

Op recept

Verenigde Staten

Op recept

Frequently asked questions

What is the difference between Bremelanotide and Sekretin?

Bremelanotide is classified as "Onderzoek (overig)", while Sekretin is classified as "Onderzoek (overig)". Bremelanotide: Synthetic cyclic heptapeptide acting as a non-selective melanocortin-receptor agonist. FDA-approved in 2019 as Vyleesi for hypoactive sexual desire disorder (HSDD) in pre-menopausal women. Sekretin: Secretin is a 27-amino-acid hormone that regulates pancreatic bicarbonate secretion. As ChiRhoStim it is FDA-approved as a diagnostic agent (pancreatic function test, gastrinoma test, secretin-enhanced MRCP). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Bremelanotide or Sekretin?

The highest available evidence level is "Humane RCT" for Bremelanotide and "Humane studie" for Sekretin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Bremelanotide and Sekretin in Germany and the United States?

Duitsland: Bremelanotide — Niet goedgekeurd, Sekretin — Op recept. Verenigde Staten: Bremelanotide — Op recept, Sekretin — Op recept. These are factual summaries with source and review date on the individual pages.