Сравнение
Bremelanotide vs. Selank
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Исследования (прочее)
Исследования (прочее)
Номер CAS
189691-06-3
129954-34-3
Молекулярная масса
1025.18 g/mol
751.85 g/mol
Период полувыведения
2.7 h
0.3 h
Последовательность
Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OHThr-Lys-Pro-Arg-Pro-Gly-ProМеханизм действия
Bremelanotide
Bremelanotide is a cyclic peptide that binds non-selectively to melanocortin receptors (MC1R through MC5R) — with highest affinity at MC4R in the central nervous system. The precise role of MC4R activation in sexual behaviour is not fully understood; animal data show effects on hypothalamic circuits. Peripheral effects (blood pressure, hyperpigmentation) are attributed to MC1R/MC2R.
Selank
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
Доказательная база
Наивысшая доказательность
РКИ на людях
Исследование на людях
Исследования
5
4
из них на людях
5
2
Зафиксированные эффекты
3
3
Открытые противоречия
1
1
Задокументированные нежелательные явления
2
1
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Bremelanotide and Selank?
- Bremelanotide is classified as "Исследования (прочее)", while Selank is classified as "Исследования (прочее)". Bremelanotide: Synthetic cyclic heptapeptide acting as a non-selective melanocortin-receptor agonist. FDA-approved in 2019 as Vyleesi for hypoactive sexual desire disorder (HSDD) in pre-menopausal women. Selank: Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trials are absent; efficacy assessment relies on Russian research literature. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Bremelanotide or Selank?
- The highest available evidence level is "РКИ на людях" for Bremelanotide and "Исследование на людях" for Selank. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Bremelanotide and Selank in Germany and the United States?
- Германия: Bremelanotide — Не одобрено, Selank — Не одобрено. США: Bremelanotide — Рецептурный, Selank — Не одобрено. These are factual summaries with source and review date on the individual pages.