Vergelijking
Bremelanotide vs. Selank
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
189691-06-3
129954-34-3
Molecuulmassa
1025.18 g/mol
751.85 g/mol
Halfwaardetijd
2.7 h
0.3 h
Sequentie
Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OHThr-Lys-Pro-Arg-Pro-Gly-ProWerkingsmechanisme
Bremelanotide
Bremelanotide is a cyclic peptide that binds non-selectively to melanocortin receptors (MC1R through MC5R) — with highest affinity at MC4R in the central nervous system. The precise role of MC4R activation in sexual behaviour is not fully understood; animal data show effects on hypothalamic circuits. Peripheral effects (blood pressure, hyperpigmentation) are attributed to MC1R/MC2R.
Selank
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane studie
Studies
5
4
waarvan bij mensen
5
2
Geregistreerde effecten
3
3
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
2
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Bremelanotide and Selank?
- Bremelanotide is classified as "Onderzoek (overig)", while Selank is classified as "Onderzoek (overig)". Bremelanotide: Synthetic cyclic heptapeptide acting as a non-selective melanocortin-receptor agonist. FDA-approved in 2019 as Vyleesi for hypoactive sexual desire disorder (HSDD) in pre-menopausal women. Selank: Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trials are absent; efficacy assessment relies on Russian research literature. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Bremelanotide or Selank?
- The highest available evidence level is "Humane RCT" for Bremelanotide and "Humane studie" for Selank. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Bremelanotide and Selank in Germany and the United States?
- Duitsland: Bremelanotide — Niet goedgekeurd, Selank — Niet goedgekeurd. Verenigde Staten: Bremelanotide — Op recept, Selank — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.