Сравнение

Semax vs. Sincalide

Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.

Идентичность

Категория

Исследования (прочее)

Номер CAS

80714-61-0

25126-32-3

Молекулярная масса

813.92 g/mol

1143.29 g/mol

Период полувыведения

0.3 h

нет данных

Последовательность

Met-Glu-His-Phe-Pro-Gly-Pro

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Механизм действия

Semax

Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Доказательная база

Наивысшая доказательность

Исследование на людях

Исследования

из них на людях

Зафиксированные эффекты

Открытые противоречия

Задокументированные нежелательные явления

Правовой статус

Country	Semax	Sincalide
Германия	Не одобрено	Неясно
RU	Рецептурный	—
США	Не одобрено	Рецептурный

Полные записи

Frequently asked questions

What is the difference between Semax and Sincalide?: Semax is classified as "Исследования (прочее)", while Sincalide is classified as "Исследования (прочее)". Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Semax or Sincalide?: The highest available evidence level is "Исследование на людях" for Semax and "Исследование на людях" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Semax and Sincalide in Germany and the United States?: Германия: Semax — Не одобрено, Sincalide — Неясно. США: Semax — Не одобрено, Sincalide — Рецептурный. These are factual summaries with source and review date on the individual pages.

Country

Semax

Sincalide

Германия

Не одобрено

Неясно

Рецептурный

—

США

Не одобрено

Рецептурный

Frequently asked questions

What is the difference between Semax and Sincalide?

Semax is classified as "Исследования (прочее)", while Sincalide is classified as "Исследования (прочее)". Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Semax or Sincalide?

The highest available evidence level is "Исследование на людях" for Semax and "Исследование на людях" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Semax and Sincalide in Germany and the United States?

Германия: Semax — Не одобрено, Sincalide — Неясно. США: Semax — Не одобрено, Sincalide — Рецептурный. These are factual summaries with source and review date on the individual pages.