Confronto

Semax vs. Sincalide

Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.

Identità

Categoria

Ricerca (altro)

N. CAS

80714-61-0

25126-32-3

Peso molecolare

813.92 g/mol

1143.29 g/mol

Emivita

0.3 h

nessun dato

Sequenza

Met-Glu-His-Phe-Pro-Gly-Pro

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Meccanismo d'azione

Semax

Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Base di evidenze

Evidenza più alta

Studio sull'uomo

Studi

di cui sull'uomo

Effetti registrati

Contraddizioni aperte

Eventi avversi documentati

Stato legale

Country	Semax	Sincalide
Germania	Non approvato	Non chiaro
RU	Su prescrizione	—
Stati Uniti	Non approvato	Su prescrizione

Voci complete

Frequently asked questions

What is the difference between Semax and Sincalide?: Semax is classified as "Ricerca (altro)", while Sincalide is classified as "Ricerca (altro)". Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Semax or Sincalide?: The highest available evidence level is "Studio sull'uomo" for Semax and "Studio sull'uomo" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Semax and Sincalide in Germany and the United States?: Germania: Semax — Non approvato, Sincalide — Non chiaro. Stati Uniti: Semax — Non approvato, Sincalide — Su prescrizione. These are factual summaries with source and review date on the individual pages.

Country

Semax

Sincalide

Germania

Non approvato

Non chiaro

Su prescrizione

—

Stati Uniti

Non approvato

Su prescrizione

Frequently asked questions

What is the difference between Semax and Sincalide?

Semax is classified as "Ricerca (altro)", while Sincalide is classified as "Ricerca (altro)". Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Semax or Sincalide?

The highest available evidence level is "Studio sull'uomo" for Semax and "Studio sull'uomo" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Semax and Sincalide in Germany and the United States?

Germania: Semax — Non approvato, Sincalide — Non chiaro. Stati Uniti: Semax — Non approvato, Sincalide — Su prescrizione. These are factual summaries with source and review date on the individual pages.